Bedard pitched seven innings of two-hit ball, and the Orioles spoiled Wakefield's return with a 4-0 victory Wednesday night.
Kevin Millar homered and Miguel Tejada had three hits for the Orioles, who improved to 2-12 against Boston this season. Bedard was the winning pitcher in Baltimore's other victory over the Red Sox, on May 17 against Wakefield.
"We had Erik Bedard win both games, so maybe he can pitch the rest of the year for us against the Red Sox," Millar said. "Seems like he's the only one that has their number right now."
Bedard (14-9) permitted only four baserunners. He allowed second-inning singles to Wily Mo Pena and Gabe Kapler, and walked Pena in the fourth and Alex Gonzalez in the sixth. The left-hander struck out five, including Kevin Youkilis three times.
"I'm proud of what I did," said Bedard, in typical low-key fashion. "I just don't show it."
Making his first appearance since July 17, Wakefield (7-9) yielded four runs on 10 hits in five innings. He was activated from the disabled list before the game after being sidelined nearly two months with a stress fracture in his rib cage.
"This was the first time in my career I had been hurt this long a period of time and rehab took longer than was expected," he said. "I am very thankful to be back rather than taking the rest of season off. ... I felt better than I thought I would feel. I wish the outcome was better."
The right-hander retired the side in order in the first inning, but struggled the rest of the way before being lifted after throwing 78 pitches.
"I actually thought he pitched pretty good considering how long he has been out," Boston manager Terry Francona said. "He said he could go further, which I agreed. I didn't think it was the prudent thing to do."
The Red Sox have lost six of seven on the road and 11 of 17 overall.
Boston's lone scoring threat came in the second inning, when singles by Pena and Kapler put runners at the corners with one out. Bedard then struck out Doug Mirabelli and retired Dustin Pedroia on a liner to short.
The rest was easy for Bedard, who never before won more than six games in a season and started the year with a 12-18 lifetime record.
"I'm more mature and more consistent with the strike zone," he said. "Before, if I got behind, I was afraid to go after it. I was nitpicking too much. Now I just throw it and let them hit it."
The Orioles took advantage of a rare lapse by the Boston defense to take a 2-0 lead in the bottom half. Singles by Tejada and Ramon Hernandez put runners on first and second for Millar, who hit into a force play. But the relay from Gonzalez skipped past first base, allowing Tejada to score.
Millar eventually reached third and scored after Mirabelli's attempted pickoff from behind the plate hit the runner and bounced into the outfield. The Red Sox came in with 57 errors, 12 fewer than any other team, and had played a club-record 98 errorless games this season.
Baltimore had runners to first and third with two outs in the third when Wakefield retired Millar on a popup. In the fourth, Wakefield got rookie Nick Markakis to hit into a fielder's choice with the bases loaded and two outs.
Millar hit his 13th homer in the fifth with a man on for a 4-0 lead. The drive came on an 0-2 pitch.
"I don't like giving up home runs on 0-2," Wakefield said.
Said Millar: "It was a pitch he probably wanted to throw for more of a ball, but it stayed over the plate. I got lucky on that one."
In the sixth, Gonzalez reached second with two outs before David Ortiz hit a twisting opposite-field liner to left that a diving Jeff Fiorentino caught near the foul line.
- Boston OF Manny Ramirez missed a third straight game with a sore right knee.
- Bedard has won two straight starts after going 0-3 over a seven-game stretch.
- Tejada is 21-for-63 (.333) with five homers lifetime against Wakefield.
- The Red Sox have won eight straight series at Camden Yards, a streak that will end if the Orioles win Thursday night.