Bonds hit his 734th career homer, but the Milwaukee Brewers rallied past San Francisco 10-8 for their third consecutive win over the struggling Giants.
The seven-time MVP hit a solo shot off Chris Capuano over the right-center fence in the third inning, just out of the reach of outfielders Brady Clark and Corey Hart. Capuano is the 434th pitcher to give up a home run to Bonds.
Bonds, who hit No. 733 and drove in a season-high six runs Friday night, is 21 homers shy of Aaron's career mark of 755. It was Bonds' 26th home run this season, and again it came in the same city where Aaron started and ended his major league career.
"It's a good accomplishment, but I just want to win," Bonds said. "It's not fun to talk right now. I wish it were a better time."
The Giants' late-season struggles have likely cost them any chance to win the NL West or grab the wild card. They have been outscored 88-48 during the first eight games of a nine-game road trip.
After winning the series opener 9-4, the Brewers have scored in the eighth inning of the past two games to break a tie each time.
"It's been a long road trip, just long," Bonds said. "Everyone is out there working hard."
Giants manager Felipe Alou agreed that the loss took a little of the luster off Bonds breaking Aaron's NL record.
"I don't believe the main thing here is the record, those guys want to win the game," Alou said. "This is an ugly road trip."
Capuano said the pitch Bonds hit for a home run was a fastball "pretty much down the middle of the plate."
"I know it's Barry Bonds up there," Capuano said. "But I know if I make my pitches, I'll get him out. I just happened to get lazy with one thing."
Brewers manager Ned Yost called Bonds "a special talent."
"He's a once-in-a-lifetime guy," Yost said. "He works real hard to keep himself in shape."
The Brewers scored twice in the eighth to break an 8-all tie and win their fourth straight game overall. Tony Graffanino singled with one out and stole second. Prince Fielder struck out, but Bill Hall lined an RBI double down the right-field line.
Hart then hit a soft fly to right fielder Moises Alou, who dropped it for a two-base error that allowed Hall to score.
Yost said the clutch hit by Hall was the key. Hall also had a key hit in the Brewers' eighth-inning rally on Friday and scored the go-ahead run.
"Billy has been huge two nights in a row," Yost said. "His approach has been fantastic. I'm really proud of Billy."
"I fell behind guys and ended up paying for it," Lowry said. "I was mostly going with my fastball and it was getting hit."
Jose Capellan (4-2) pitched a perfect eighth for the win and Francisco Cordero worked a scoreless ninth to convert his 15th save 15 chances with Milwaukee. Capuano lasted 5 1/3 innings, giving up seven runs and 11 hits.
Moises Alou had a home run and two doubles.
San Francisco, which trailed 6-1 after two innings, came back to grab the lead in the sixth on Randy Winn's RBI double, his third double of the game, and Omar Vizquel's RBI single to make it 7-6.
Eliezer Alfonzo's RBI groundout in the seventh increased the lead to 8-6.
But in the bottom half, David Bell knocked in a run with a fielder's choice and scored on a wild pitch by Taschner to tie it at 8.
- Capuano made a diving catch of a bunt attempt by Vizquel in the first inning. The pitcher was shaken up on the play, but remained in the game.
- Giants C Todd Greene left in the third with a bruised thigh after being hit by a foul ball. San Francisco 2B Ray Durham left in the sixth after fouling a ball off his knee.