DENVER -- Dustin Pedroia was hitting the ball all over the place. Most of all out of the yard.

Pedroia went 5 for 5 with three home runs, including a tiebreaking shot off Huston Street in the 10th inning, to lift the Boston Red Sox past the Colorado Rockies 13-11 in a wild game Thursday night that lasted nearly five hours.

Boston averted a series sweep in a rematch of the 2007 World Series and bailed out closer Jonathan Papelbon after he squandered a late lead at Coors Field for the second successive night.

"That was a crazy game," said Pedroia, who matched a career high with five RBI. "It was mentally draining. I'm just happy we won."

Marco Scutaro singled with one out in the 10th and Pedroia sent a shot into the left-field bleachers off Street (0-1), who just recently was activated after spending 2½ months on the disabled list with right shoulder inflammation and a strained left groin.

"I knew he got it good. It sounded good," Street said.

Pedroia wasn't so sure he got enough of Street's hanging slider, though.

"In the thin air, I was hoping it would get in the first or second row," said Pedroia, the 2008 AL MVP. "I didn't see where it went. I just saw the left fielder put his head down. I'm like, 'That's awesome.' "

As the diminutive Pedroia made his way to the dugout afterward, David Ortiz greeted him with a big bear hug.

A well-earned one at that since this was Pedroia's first three-homer game, including Little League, high school -- anywhere.

"I've been feeling good at the plate lately, been seeing the ball good, hitting the ball all over the place," Pedroia said. "When you feel good, the only thing is you've got to get a good pitch to hit. Tonight, I got good pitches to hit and I didn't miss them."

Despite blowing a save opportunity for the second successive game, Papelbon (3-4) picked up the victory by pitching the final two innings.

Brad Hawpe tied it in the ninth with a two-run single off Papelbon, one night after the All-Star closer gave up a game-winning home run to pinch-hitter Jason Giambi.

Seth Smith nearly ended this one soon after, driving the ball to the deepest part of the park, where center fielder Darnell McDonald tracked it down with his back against the wall.

So close, Rockies manager Jim Tracy lamented.

"A shoulder width's length to the right off the bat of Seth Smith, and we win the game," Tracy said.

The teams combined to use 14 pitchers in a back-and-forth marathon that lasted 4 hours, 48 minutes and capped a dramatic series.

Giambi came through with a two-run shot Wednesday, his fifth career game-ending home run. On Tuesday, Rockies shortstop Clint Barmes made a diving stop on Mike Lowell's hard-hit grounder deep in the hole, rolling over and firing to first to beat a hobbling Lowell for the final out of a 2-1 victory.

Then there was this game, which featured 33 hits, including a season-high 18 by the Rockies.

Pedroia, who scored four times, had the first three-homer game of his career. He had a pair of two-run shots, a solo home run, a double, a single and a walk.

"When he's locked, he's as dangerous as anybody," Red Sox manager Terry Francona said.

Adrian Beltre hit a two-run homer and later added an RBI single as Boston avoided a sweep at Coors Field, where the Red Sox celebrated their sweep of the 2007 World Series.

Leading 6-2 after a solid five-inning effort from starter Daisuke Matsuzaka in his return to the mound, Boston put the game in the hands of the bullpen.

Only the relievers couldn't make it hold up as the Rockies rallied for six runs in the sixth to reclaim an 8-6 lead. Ian Stewart and Todd Helton each had a two-run single in the inning.

Colorado's bullpen didn't fare much better, giving the lead right back in a three-run seventh. Jason Varitek had the big blow with a two-run double off Manny Corpas.

Matsuzaka was reinstated from the disabled list before the game after missing more than two weeks with a strained forearm.

After a shaky beginning, the right-hander settled in, giving up five hits and two runs.

The Red Sox roughed up Jason Hammel, who entered with a 0.31 ERA this month. That figure was quickly elevated to 1.35 with the help of Boston's four-run rally in the fourth, which snapped Hammel's scoreless streak at 28 1/3 innings.

"We did a good job of actually keeping Pedroia off the board -- until tonight," Hammel said. "He went off."

Notes

• It was the sixth three-homer game in the majors this season and first since Albert Pujols accomplished the feat May 30 at Chicago.
• To make room for Matsuzaka on the roster, Boston placed Lowell on the DL with a right hip injury.
• Hawpe drove in a season-high four runs.