TORONTO -- One day after swatting his 50th home run, Jose Bautista delivered an emphatic encore.
"It's still hard for me to believe it but I'm not going to change a thing," Bautista said. "I'm going to reflect on it once the season is over."
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The Blue Jays have won 12 straight over the Orioles in Toronto and 21 of the past 23 meetings. They are 13-3 against Baltimore this season, outscoring the Orioles 83-44 and outhomering them 30-7.
Left-hander Brett Cecil (14-7) gave up three runs in 6 1/3 innings and improved to 3-0 in four career starts against the Orioles.
Shawn Camp got two outs and Jason Frasor worked an inning, but closer Kevin Gregg was lifted after giving up an RBI double to pinch-hitter Corey Patterson then falling behind 2-0 to pinch-hitter Matt Wieters. Jesse Carlson came on and got Wieters to fly out for his first save of the season and third of his career.
It was the eighth multihomer game of the season for Bautista, who went 2 for 2 with three RBI and two walks. Bautista has walked 98 times this season, second in the AL to Oakland's Daric Barton.
"I've learned over the course of the season not to put any limitations on what he can do," Wells said. "The amazing thing is when he gets his pitch he's not missing it. And if they're not going to pitch to him, he's not going to swing."
Bautista has connected nine times against the Orioles this season. Only two other players have hit as many homers against Baltimore in a season. Toronto's Tony Batista did it in 2000, while Washington's Frank Howard did it in 1968.
"His contact-to-damage ratio is pretty good and unfortunately we were on the receiving end," Orioles manager Buck Showalter said.
The Blue Jays lead the majors with 237 home runs, including a major league-high 136 at home, the most in team history. Toronto connected 134 times at home in 2000, hitting a team-record 244.
Bautista became the 26th player in baseball history to reach the 50-homer mark with a game-winning blast against Seattle on Thursday. He celebrated by going to dinner with his parents, in town from the Dominican Republic for the weekend, then immediately starting adding to his total with a solo drive in the first inning Friday.
Wells hit a two-run drive in the fourth, his 30th, before Bautista connected again in the sixth, a two-run shot that landed in the second deck in left.
Wells and Bautista have combined for 82 home runs this season, more than any other pair of teammates in the majors.
All three homers came off Baltimore right-hander Chris Tillman (1-5), who allowed five runs and four hits in six innings. Tillman, who is winless in five starts, walked one and struck out three.
"With this team you have to be more dialed in than others," Tillman said. "They live and die by the long ball."
Nick Markakis and Ty Wigginton both had three hits for the Orioles, who outhit Toronto 16-5. It's the biggest deficit the Blue Jays have ever faced in a victory. Toronto beat Cleveland 2-1 on Oct. 2, 1977, despite being outhit 11-2.
"It's strange that could happen but when most of your runs come from home runs, that's what's going to happen," Wells said.
Cecil matched a career high by allowing 11 hits. He struck out four.
Orioles infielder Brandon Snyder canceled Bautista's first homer with an RBI double in the second, but Baltimore didn't score again until the sixth, chasing Cecil one out after consecutive doubles from Brian Roberts and Markakis made it 5-2.
Camp came on and gave up a single to Wigginton and got pinch-hitter Luke Scott to fly out but Nolan Reimold hit an RBI single. Camp got out of it by fanning Craig Tatum.
After Matt Albers loaded the bases with a single and two walks in the eighth, Mark Hendrickson came on and walked Lyle Overbay to make it 6-3.
Wells is the fourth Blue Jay to record at least three 30-homer seasons, joining Joe Carter, Carlos Delgado and Fred McGriff ... Orioles RHP Rick VandenHurk is expected to come out of the bullpen to start Sunday's series finale. ... Milwaukee's Prince Fielder is the only NL player to have walked more times than Bautista.