OAKLAND, Calif. -- Brett Anderson's streak for not allowing an extra-base hit to a left-handed batter this season ended with a thud on the Oakland pitcher's fourth offering of the game.
Curtis Granderson's two-run homer was only just the beginning of Anderson's long night.
Granderson added a two-run single, Robinson Cano homered and the New York Yankees handed Anderson the most lopsided beating of his career with a 10-3 win Tuesday.
"It just didn't seem to work for Brett tonight," Oakland manager Bob Geren said. "He was aggressive, came right at them, and that was the plan. The homers were what made it work for them. They seemed to score every inning. It just wasn't his night."
Granderson's homer, coming after Derek Jeter's single on the first pitch of the game, was only the fifth surrendered by Anderson (3-5) this season and the first to a left-hander since Aug. 25, 2009.
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Anderson, who allowed three home runs to Texas on April 30, was tagged for career-highs in runs (10) and hits (11) while losing for the third time in his last four starts.
"I was pretty unsuccessful all around," Anderson said. "Minus the home runs I feel like I made some pitches to get some outs that I just didn't get. Then I make a bad pitch to Cano that he hits a bomb off. But you have to give them credit. They set the tone early and kept on punching."
Oakland didn't help much defensively.
The A's were charged with only one error but also botched a rundown in the sixth that allowed Mark Teixeira to steal home to give New York a seven-run lead.
Jeter had two hits to reach 2,983 for his career and scored three runs and Alex Rodriguez had three hits and three RBI for the Yankees, who won their ninth straight against Oakland. It's New York's longest winning streak against the A's since 1964-65, when the team was based in Kansas City.
The A's have lost 22 of 25 meetings against the Yankees. With consecutive wins to open this three-game set, New York has become the first team to win nine straight series against the A's since the team moved to Oakland in 1968.
Freddy Garcia (4-4) allowed three runs and nine hits in seven innings of his 300th career start. He allowed only a two-run homer and an RBI single to David DeJesus to beat the A's for just the second time in his last 10 starts against them.
That performance proved to be more than enough on a night the Yankees knocked around Anderson with ease. Anderson hadn't allowed an extra-base hit to a left-handed hitter all season and a homer to a lefty since Russell Branyan hit one for Seattle almost three years ago, before Granderson and Cano connected for two-run homers in the first and fifth innings, respectively.
That led to another rough outing for Anderson against the powerful Yankees as he allowed nine earned runs in 5 1/3 innings. That dropped Anderson's record to 0-4 with a 6.53 ERA in five career starts against New York.
Even when the Yankees made mistakes, they were able to turn them into runs.
Rodriguez got caught too far off first after Cano struck out for the second out in the sixth inning. With Rodriguez in a rundown, Teixeira broke from third to home and scored on a stolen base when first baseman Conor Jackson's throw was off line.
For the second straight game, the Yankees got a two-run homer in the first inning to take a lead before the A's even came to the plate. A day after Teixeira hit his 16th homer in the opening inning off Trevor Cahill, Granderson hit his 17th after Jeter led off the game with a single off second baseman Mark Ellis' glove.
The Yankees added an unearned run in the third when Jeter reached on Ellis' two-base throwing error and scored on Rodriguez's bloop hit.
"It seems you face one guy and then another guy that's an All-Star, then a potential Hall of Famer comes up and it's tough," Anderson said. "It's another big league lineup you have to go through and battle and I just didn't do a good job of it tonight."
After DeJesus' RBI single got Oakland on the board for the first time this series in the bottom of the third, Granderson extended the lead to 5-1 with a two-out, bases-loaded single in the fourth.
Cano's 11th homer and Rodriguez's two-run single helped the Yankees break the game open.
Anderson's outing snapped a streak of 28 straight games that Oakland's starter had allowed four runs or fewer. ... The A's are giving slumping 1B Daric Barton (.206 average, 0 HRs) a few days off to work on his batting stroke. ... Ellis' fielding gaffe was only his second of the season and ended a 35-game errorless streak. ... IF Andy LaRoche tripled in the third and scored Oakland's first run. It was LaRoche's first triple since Aug. 1, 2009.