| Passing | ||||
| CP/AT | YDS | TD | INT | |
| A. Smith | 17/28 | 222 | 1 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 23 | 107 | 2 | 34 |
| G. Coffee | 2 | 12 | 0 | 9 |
| M. Norris | 3 | 5 | 1 | 2 |
| A. Smith | 4 | 1 | 0 | 4 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| V. Davis | 6 | 89 | 1 | 73 |
| M. Crabtree | 3 | 58 | 0 | 38 |
| J. Morgan | 2 | 27 | 0 | 17 |
| F. Gore | 2 | 25 | 0 | 22 |
| J. Hill | 2 | 17 | 0 | 12 |
| D. Walker | 2 | 6 | 0 | 5 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| A. Battle | 1 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| S. Andrus | 0/0 | 0 | 4/4 | 4 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 9 | 46.7 | 2 | 56 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| J. Morgan | 2 | 20.0 | 0 | 22 |
| M. Robinson | 1 | 12.0 | 0 | 12 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| A. Battle | 5 | 8.2 | 0 | 18 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| J. Smith | 8-0 | 3.5 | 0 | 0 |
| M. Lewis | 5-0 | 0.0 | 0 | 0 |
| P. Willis | 5-0 | 0.0 | 0 | 0 |
| P. Haralson | 4-1 | 0.5 | 0 | 0 |
| D. Bly | 3-0 | 1.0 | 0 | 0 |
| T. Brown | 3-0 | 0.0 | 0 | 0 |
| D. Evans | 3-0 | 1.0 | 0 | 0 |
| D. Goldson | 3-1 | 1.0 | 0 | 0 |
| M. Roman | 3-0 | 0.0 | 0 | 0 |
| A. Franklin | 2-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 2-0 | 0.0 | 0 | 0 |
| A. Brooks | 1-0 | 0.0 | 0 | 0 |
| M. Lawson | 1-0 | 1.0 | 0 | 0 |
| S. Spencer | 1-0 | 0.0 | 0 | 0 |
| T. Spikes | 1-0 | 0.0 | 0 | 0 |
|
|
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| 4th Quarter | |
| San Francisco at 2:22 | |
| 2-6-STL 6 | (2:22) F.Gore left tackle for 6 yards, TOUCHDOWN. |
| S.Andrus extra point is GOOD, Center-B.Jennings, Holder-A.Lee. | |
| S.Andrus kicks 65 yards from SF 30 to SL 5. D.Amendola to SL 26 for 21 yards (A.Battle). | |
| St. Louis at 2:10 | |
| 1-10-STL 26 | (2:10) (Shotgun) K.Boller pass incomplete short left to R.McMichael. |
| 2-10-STL 26 | (2:05) (Shotgun) C.Ogbonnaya up the middle to SL 25 for -1 yards (D.Evans). |
| 3-11-STL 25 | (2:00) (Shotgun) K.Boller pass incomplete short right to B.Gibson. |
| 4-11-STL 25 | (1:56) D.Jones punts 53 yards to SF 22, Center-R.Neill, fair catch by A.Battle. |
| San Francisco at 1:48 | |
| 1-10-SF 22 | (1:48) M.Norris up the middle to SF 24 for 2 yards (V.Adeyanju). |
| 2-8-SF 24 | (1:08) A.Smith kneels to SF 23 for -1 yards. |
| 3-9-SF 23 | (:25) A.Smith kneels to SF 22 for -1 yards. |
| 1st Quarter | ||
| None | ||
| 2nd Quarter | ||
| FG | Josh Brown 54 Yd, 4:00. Drive: 7 plays, 29 yards in 1:57. | |
| 3rd Quarter | ||
| TD | Moran Norris, 1 Yd run (Shane Andrus kick is good), 7:58. Drive: 8 plays, 83 yards in 4:03. | |
| 4th Quarter | ||
| FG | Josh Brown 29 Yd, 9:11. Drive: 4 plays, 8 yards in 2:06. | |
| TD | Vernon Davis, 73 Yd pass from Alex Smith (Shane Andrus kick is good), 7:29. Drive: 3 plays, 82 yards in 1:42. | |
| TD | Frank Gore, 3 Yd run (Shane Andrus kick is good), 4:05. Drive: 4 plays, 51 yards in 2:14. | |
| TD | Frank Gore, 6 Yd run (Shane Andrus kick is good), 2:16. Drive: 4 plays, 27 yards in 0:26. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| K. Null | 7/17 | 57 | 0 | 0 |
| K. Boller | 4/11 | 23 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| S. Jackson | 20 | 63 | 0 | 13 |
| K. Boller | 1 | 13 | 0 | 13 |
| K. Null | 3 | 6 | 0 | 3 |
| C. Ogbonnaya | 2 | 5 | 0 | 6 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Avery | 2 | 23 | 0 | 20 |
| D. Amendola | 3 | 18 | 0 | 9 |
| B. Gibson | 3 | 18 | 0 | 8 |
| R. Martin | 1 | 9 | 0 | 9 |
| R. McMichael | 1 | 7 | 0 | 7 |
| J. Kent | 1 | 5 | 0 | 5 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| Kicking | ||||
| FG | LG | XP | PTS | |
| J. Brown | 2/3 | 54 | 0/0 | 6 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| D. Jones | 11 | 50.1 | 2 | 62 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| D. Amendola | 5 | 22.2 | 0 | 24 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| D. Amendola | 5 | 14.6 | 0 | 56 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| R. Bartell | 5-0 | 0.0 | 0 | 0 |
| J. Butler | 5-0 | 0.0 | 0 | 0 |
| J. Hall | 5-0 | 1.0 | 0 | 0 |
| J. Laurinaitis | 5-0 | 1.0 | 0 | 0 |
| P. Lenon | 5-0 | 0.0 | 0 | 0 |
| J. King | 4-0 | 0.0 | 0 | 0 |
| C. Dahl | 3-0 | 1.0 | 0 | 0 |
| C. Long | 3-0 | 0.0 | 0 | 0 |
| C. Ryan | 3-0 | 0.0 | 0 | 0 |
| D. Vobora | 3-0 | 0.0 | 0 | 0 |
| J. Wade | 2-0 | 0.0 | 0 | 0 |
| V. Adeyanju | 1-0 | 0.0 | 0 | 0 |
| C. Chamberlain | 1-0 | 0.0 | 0 | 0 |
| L. Douzable | 1-0 | 0.0 | 0 | 0 |
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