| Passing | ||||
| CP/AT | YDS | TD | INT | |
| A. Smith | 14/26 | 179 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 23 | 83 | 1 | 14 |
| K. Hunter | 12 | 73 | 0 | 24 |
| A. Smith | 5 | 22 | 0 | 12 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| M. Crabtree | 5 | 85 | 0 | 41 |
| V. Davis | 4 | 54 | 0 | 17 |
| F. Gore | 1 | 13 | 0 | 13 |
| K. Hunter | 1 | 11 | 0 | 11 |
| B. Edwards | 1 | 9 | 0 | 9 |
| K. Williams | 1 | 4 | 0 | 4 |
| B. Miller | 1 | 3 | 0 | 3 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| A. Smith | 1 | 0 | 1 | 0 |
| D. Whitner | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 4/5 | 53 | 1/1 | 13 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 2 | 54.0 | 0 | 60 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| K. Williams | 3 | 28.7 | 0 | 33 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| K. Williams | 2 | 20.5 | 0 | 36 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Bowman | 7-5 | 1.0 | 0 | 0 |
| L. Grant | 6-6 | 0.0 | 0 | 1 |
| R. McDonald | 3-4 | 1.0 | 0 | 0 |
| A. Smith | 3-1 | 1.0 | 0 | 0 |
| C. Culliver | 2-0 | 0.0 | 0 | 0 |
| C. Rogers | 2-0 | 0.0 | 0 | 0 |
| C. Spillman | 2-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 2-5 | 0.0 | 0 | 0 |
| D. Whitner | 2-1 | 0.0 | 0 | 0 |
| J. Smith | 2-3 | 0.0 | 0 | 0 |
| B. Miller | 1-1 | 0.0 | 0 | 0 |
| P. Haralson | 1-0 | 0.0 | 0 | 0 |
| T. Brown | 1-0 | 0.0 | 0 | 0 |
| B. Costanzo | 1-0 | 0.0 | 0 | 0 |
| A. Brooks | 1-1 | 0.0 | 0 | 0 |
| T. Gooden | 1-0 | 0.0 | 0 | 0 |
| D. Goldson | 1-2 | 0.0 | 0 | 0 |
|
|
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| 4th Quarter | |
| Seattle at 1:18 | |
| 3-3-SF 48 | (1:18) T.Jackson scrambles right end to SF 46 for 2 yards (L.Grant). FUMBLES (L.Grant), RECOVERED by SF-D.Whitner at SF 36. D.Whitner to SF 36 for no gain (L.Jeanpierre). |
| San Francisco at 1:07 | |
| 1-10-SF 36 | (1:07) F.Gore right guard to SF 42 for 6 yards (K.Wright). |
| 2-4-SF 42 | (1:02) F.Gore left tackle to SF 42 for no gain (A.Branch). |
| 3-4-SF 42 | (:58) Alex Smith sacked at SF 38 for -4 yards (A.Branch). |
| 4-8-SF 38 | (:52) A.Lee punts 60 yards to SEA 2, Center-B.Jennings. L.Washington to SEA 26 for 24 yards (L.Grant). |
| Seattle at :41 | |
| 1-10-SEA 26 | (:41) (Shotgun) T.Jackson pass short left to J.Forsett to SEA 34 for 8 yards (T.Brown, L.Grant) [Ald.Smith]. |
| 2-2-SEA 34 | (:24) T.Jackson spiked the ball to stop the clock. |
| 3-2-SEA 34 | (:23) (Shotgun) T.Jackson pass incomplete deep middle to D.Baldwin. |
| 4-2-SEA 34 | (:18) (Shotgun) T.Jackson pass incomplete short right to Z.Miller. |
| San Francisco at :13 | |
| 1-10-SEA 34 | (:13) Alex Smith kneels to SEA 35 for -1 yards. |
| 1st Quarter | ||
| TD | Doug Baldwin, 13 Yd pass from Tarvaris Jackson (Steven Hauschka kick is good), 11:35. Drive: 7 plays, 80 yards in 3:25. | |
| 2nd Quarter | ||
| FG | David Akers, 53 Yd, 14:28. Drive: 11 plays, 56 yards in 5:54. | |
| FG | Steven Hauschka, 19 Yd, 1:30. Drive: 12 plays, 42 yards in 5:09. | |
| 3rd Quarter | ||
| TD | Frank Gore, 4 Yd run (David Akers kick is good), 11:01. Drive: 8 plays, 75 yards in 3:59. | |
| FG | David Akers, 29 Yd, 4:04. Drive: 10 plays, 37 yards in 5:20. | |
| 4th Quarter | ||
| FG | David Akers, 44 Yd, 12:37. Drive: 9 plays, 40 yards in 4:45. | |
| TD | Marshawn Lynch, 4 Yd run (Steven Hauschka kick is good), 6:41. Drive: 1 play, 4 yards in 0:06. | |
| FG | David Akers, 39 Yd, 2:57. Drive: 6 plays, 40 yards in 3:44. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| T. Jackson | 15/28 | 163 | 1 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| M. Lynch | 21 | 107 | 1 | 18 |
| L. Washington | 2 | 9 | 0 | 5 |
| T. Jackson | 3 | 5 | 0 | 3 |
| J. Forsett | 1 | 5 | 0 | 5 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| R. Lockette | 1 | 44 | 0 | 44 |
| M. Lynch | 2 | 24 | 0 | 20 |
| J. Forsett | 2 | 20 | 0 | 12 |
| B. Obomanu | 2 | 20 | 0 | 14 |
| D. Baldwin | 2 | 17 | 1 | 13 |
| G. Tate | 3 | 16 | 0 | 8 |
| D. Butler | 2 | 13 | 0 | 7 |
| Z. Miller | 1 | 9 | 0 | 9 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| T. Jackson | 1 | 1 | 0 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| S. Hauschka | 1/1 | 19 | 2/2 | 5 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| J. Ryan | 5 | 45.4 | 2 | 64 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. Washington | 5 | 21.4 | 0 | 24 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| L. Washington | 1 | 24.0 | 0 | 24 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| K. Chancellor | 10-0 | 0.0 | 0 | 0 |
| B. Browner | 5-0 | 0.0 | 0 | 0 |
| R. Sherman | 5-0 | 0.0 | 0 | 0 |
| K. Wright | 5-0 | 0.0 | 0 | 0 |
| B. Mebane | 5-2 | 0.0 | 0 | 0 |
| C. Clemons | 4-2 | 0.0 | 0 | 0 |
| D. Hawthorne | 3-4 | 0.0 | 0 | 0 |
| L. Hill | 3-2 | 1.0 | 0 | 0 |
| A. Branch | 3-1 | 1.0 | 0 | 0 |
| E. Thomas | 3-1 | 0.0 | 0 | 0 |
| R. Bryant | 2-0 | 0.0 | 0 | 0 |
| C. Maragos | 1-0 | 0.0 | 0 | 0 |
| A. Bigby | 1-1 | 0.0 | 0 | 0 |
| L. Jeanpierre | 1-0 | 0.0 | 0 | 0 |
| J. Ryan | 1-0 | 0.0 | 0 | 0 |
| R. Brock | 0-3 | 0.0 | 0 | 0 |
| M. Robinson | 0-1 | 0.0 | 0 | 0 |
| A. Hargrove | 0-1 | 0.0 | 0 | 0 |
| B. Maxwell | 0-1 | 0.0 | 0 | 0 |
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