| Passing | ||||
| CP/AT | YDS | TD | INT | |
| P. Rivers | 8/10 | 89 | 0 | 1 |
| C. Whitehurst | 5/15 | 63 | 0 | 0 |
| J. Lee | 4/13 | 26 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| J. Battle | 10 | 35 | 0 | 5 |
| R. Brown | 5 | 25 | 0 | 8 |
| E. Baker | 4 | 9 | 0 | 4 |
| L. McClain | 2 | 7 | 0 | 6 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| A. Gates | 3 | 44 | 0 | 21 |
| M. Floyd | 2 | 29 | 0 | 18 |
| R. Goodman | 3 | 23 | 0 | 10 |
| R. Brown | 2 | 19 | 0 | 14 |
| M. Spurlock | 2 | 19 | 0 | 15 |
| R. McMichael | 2 | 18 | 0 | 14 |
| E. Royal | 1 | 10 | 0 | 10 |
| E. Baker | 1 | 9 | 0 | 9 |
| L. McClain | 1 | 7 | 0 | 7 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| A. Gates | 1 | 1 | 0 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| N. Kaeding | 1/1 | 27 | 0/0 | 3 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| R. Malone | 7 | 45.7 | 1 | 59 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| D. Presley | 5 | 23.8 | 0 | 27 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| D. Presley | 2 | 2.5 | 0 | 3 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| A. Gachkar | 7-0 | 1.0 | 0 | 0 |
| B. Taylor | 7-0 | 0.0 | 0 | 0 |
| D. Presley | 4-0 | 0.0 | 0 | 0 |
| C. Lynch | 4-0 | 0.0 | 0 | 0 |
| B. Bird | 3-0 | 1.0 | 1 | 0 |
| J. Mouton | 3-1 | 0.0 | 0 | 0 |
| R. Elmore | 3-1 | 0.0 | 0 | 0 |
| D. Gamble | 2-0 | 0.0 | 0 | 0 |
| C. Thomas | 2-0 | 0.0 | 0 | 0 |
| T. Spikes | 2-1 | 0.0 | 0 | 0 |
| S. Phillips | 2-0 | 0.0 | 0 | 0 |
| A. Barnes | 1-0 | 0.0 | 0 | 0 |
| S. Cattouse | 1-0 | 0.0 | 0 | 0 |
| A. Cason | 1-0 | 0.0 | 0 | 0 |
| C. Bryant | 1-0 | 0.0 | 0 | 0 |
| C. Liuget | 1-0 | 0.0 | 0 | 0 |
| D. Scafe | 1-2 | 0.0 | 0 | 0 |
| A. Franklin | 1-0 | 0.0 | 0 | 0 |
| G. Gatson | 1-0 | 0.0 | 0 | 0 |
| A. Bigby | 1-1 | 0.0 | 0 | 0 |
| D. Butler | 1-0 | 0.0 | 0 | 0 |
| E. Weddle | 0-2 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| San Diego | 0 | 0 | 0 | 3 |
| San Francisco | 14 | 7 | 14 | 0 |
| 1st Quarter | ||
| TD @ 10:04 | Anthony Dixon runs for 1 yard (David Akers kick is good). Drive: 11 plays, 66 yards in 4:56. | |
| TD @ 6:17 | Delanie Walker catches a 32 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 2 plays, 32 yards in 0:15. | |
| 2nd Quarter | ||
| TD @ 8:11 | A.J. Jenkins catches a 12 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 6 plays, 62 yards in 2:44. | |
| 3rd Quarter | ||
| TD @ 9:06 | Nathan Palmer catches a 51 yard pass from Josh Johnson (David Akers kick is good). Drive: 1 play, 51 yards in 0:08. | |
| TD @ 0:54 | Garrett Celek catches a 3 yard pass from Josh Johnson (David Akers kick is good). Drive: 12 plays, 75 yards in 7:02. | |
| 4th Quarter | ||
| FG @ 11:27 | Nate Kaeding makes a 27 yard kick. Drive: 4 plays, 1 yards in 0:59. | |
| 4th Quarter | |
| 2-1-SF 41 | (4:43) W.Tukuafu reported in as eligible. J.Johnson pass incomplete short right to W.Tukuafu (D.Gamble). |
| 3-1-SF 41 | (4:33) W.Tukuafu reported in as eligible. A.Dixon up the middle to SF 47 for 6 yards (A.Gachkar). |
| 1-10-SF 47 | (3:54) A.Dixon right end to SF 48 for 1 yard (C.Bryant, J.Mouton). |
| 2-9-SF 48 | (3:11) J.Johnson pass incomplete short left to C.Owusu. |
| 3-9-SF 48 | (3:08) (Shotgun) J.Johnson pass short right to N.Palmer to SD 38 for 14 yards (G.Gatson). Caught at SD38. 0-yds YAC |
| 1-10-SD 38 | (2:25) L.James left end to SD 31 for 7 yards (D.Gamble). |
| 2-3-SD 31 | (2:00) (Shotgun) J.Johnson scrambles right tackle to SD 5 for 26 yards (R.Elmore). |
| 1-5-SD 5 | (1:12) PENALTY on SF-J.Johnson, Delay of Game, 5 yards, enforced at SD 5 - No Play. |
| 1-10-SD 10 | (1:07) J.Johnson pass short left to K.Reuland to SD 1 for 9 yards (B.Taylor). Caught at SD5. 4-yds YAC |
| 2-1-SD 1 | (:24) W.Tukuafu reported in as eligible. J.Johnson kneels to SD 2 for -1 yards. |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| C. Kaepernick | 12/18 | 158 | 2 | 0 |
| J. Johnson | 9/14 | 125 | 2 | 0 |
| S. Tolzien | 3/8 | 42 | 0 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| A. Dixon | 12 | 55 | 1 | 17 |
| J. Johnson | 5 | 50 | 0 | 26 |
| L. James | 5 | 27 | 0 | 7 |
| K. Hunter | 4 | 23 | 0 | 9 |
| A. Jenkins | 1 | 9 | 0 | 9 |
| C. Kaepernick | 1 | 7 | 0 | 7 |
| R. Cartwright | 2 | 5 | 0 | 4 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| N. Palmer | 3 | 72 | 1 | 51 |
| A. Jenkins | 4 | 59 | 1 | 24 |
| G. Celek | 3 | 54 | 1 | 37 |
| B. Swain | 3 | 38 | 0 | 20 |
| D. Walker | 1 | 32 | 1 | 32 |
| L. James | 2 | 26 | 0 | 13 |
| K. Reuland | 4 | 22 | 0 | 9 |
| R. Cartwright | 2 | 10 | 0 | 5 |
| B. Miller | 1 | 9 | 0 | 9 |
| C. Owusu | 1 | 3 | 0 | 3 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| L. James | 2 | 0 | 2 | 0 |
| J. Johnson | 1 | 0 | 1 | 0 |
| T. Robinson | 0 | 0 | 1 | 22 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 0/1 | 0 | 5/5 | 5 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 4 | 38.8 | 2 | 42 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. James | 2 | 30.0 | 0 | 39 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| L. James | 4 | 7.5 | 0 | 11 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| I. Williams | 4-0 | 0.0 | 0 | 0 |
| T. Gooden | 3-3 | 1.0 | 0 | 0 |
| C. Spillman | 3-1 | 0.0 | 0 | 1 |
| T. Brock | 3-0 | 0.0 | 0 | 0 |
| M. Masifilo | 3-1 | 0.0 | 0 | 0 |
| C. Culliver | 3-1 | 0.0 | 0 | 0 |
| M. Wilhoite | 2-0 | 0.0 | 0 | 0 |
| C. Johnson | 2-0 | 0.0 | 0 | 0 |
| L. Grant | 2-1 | 0.0 | 0 | 0 |
| A. Mosley | 2-0 | 0.0 | 0 | 0 |
| I. Alama-Francis | 2-1 | 0.5 | 0 | 0 |
| E. Bakhtiari | 2-1 | 0.5 | 0 | 0 |
| D. McBath | 1-0 | 0.0 | 1 | 0 |
| W. Tukuafu | 1-0 | 0.0 | 0 | 0 |
| K. Rowe | 1-0 | 0.0 | 0 | 0 |
| P. Cox | 1-0 | 0.0 | 0 | 0 |
| J. Holland | 1-0 | 0.0 | 0 | 0 |
| T. Jerod-Eddie | 1-0 | 0.0 | 0 | 0 |
| T. Robinson | 1-0 | 0.0 | 0 | 0 |
| K. Nelson | 1-0 | 0.0 | 0 | 0 |
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