| Passing | ||||
| CP/AT | YDS | TD | INT | |
| S. Bradford | 19/39 | 209 | 1 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| S. Jackson | 19 | 64 | 1 | 12 |
| S. Bradford | 4 | 13 | 0 | 11 |
| D. Richardson | 3 | 4 | 0 | 2 |
| C. Givens | 1 | -3 | 0 | -3 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| B. Gibson | 6 | 100 | 1 | 24 |
| L. Kendricks | 3 | 36 | 0 | 22 |
| A. Pettis | 5 | 33 | 0 | 9 |
| C. Givens | 3 | 25 | 0 | 13 |
| S. Jackson | 1 | 9 | 0 | 9 |
| B. Quick | 1 | 6 | 0 | 6 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| J. Hekker | 1 | 0 | 1 | 0 |
| S. Bradford | 1 | 0 | 1 | 0 |
| J. Laurinaitis | 0 | 0 | 1 | 4 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| G. Zuerlein | 0/0 | 0 | 1/1 | 1 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| J. Hekker | 8 | 37.8 | 2 | 50 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| C. Givens | 4 | 22.0 | 0 | 28 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| A. Pettis | 2 | 11.5 | 0 | 23 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| Q. Mikell | 8-1 | 0.0 | 0 | 0 |
| C. Finnegan | 6-2 | 0.0 | 0 | 0 |
| J. Jenkins | 5-1 | 0.0 | 0 | 0 |
| M. Brockers | 4-3 | 1.5 | 0 | 1 |
| D. Stewart | 4-0 | 0.0 | 0 | 0 |
| C. Dahl | 4-0 | 0.0 | 0 | 0 |
| J. Laurinaitis | 3-0 | 0.0 | 0 | 0 |
| T. Johnson | 3-0 | 0.0 | 0 | 0 |
| J. Dunbar | 3-4 | 0.0 | 1 | 0 |
| R. Quinn | 2-0 | 1.0 | 0 | 0 |
| E. Sims | 2-1 | 0.0 | 0 | 0 |
| C. Harkey | 2-0 | 0.0 | 0 | 0 |
| C. Long | 1-3 | 0.5 | 0 | 0 |
| J. Cudjo | 1-0 | 0.0 | 0 | 0 |
| B. Fletcher | 1-0 | 0.0 | 0 | 0 |
| R. McIntosh | 0-1 | 0.0 | 0 | 0 |
| R. McLeod | 0-1 | 0.0 | 0 | 0 |
| K. Langford | 0-4 | 1.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| St. Louis | 0 | 0 | 7 | 8 |
| Buffalo | 3 | 3 | 6 | 0 |
| 1st Quarter | ||
| FG @ 2:14 | Rian Lindell makes a 35 yard kick. Drive: 10 plays, 56 yards in 5:37. | |
| 2nd Quarter | ||
| FG @ 0:07 | Rian Lindell makes a 40 yard kick. Drive: 7 plays, 27 yards in 1:08. | |
| 3rd Quarter | ||
| TD @ 8:37 | Steven Jackson runs for 1 yard (Greg Zuerlein kick is good). Drive: 11 plays, 70 yards in 6:23. | |
| TD @ 3:26 | Lee Smith catches a 2 yard pass from Ryan Fitzpatrick (Rian Lindell passes to for a 2 Pt. Conversion - failed). Drive: 9 plays, 75 yards in 5:11. | |
| 4th Quarter | ||
| TD @ 0:48 | Brandon Gibson catches a 13 yard pass from Sam Bradford (Sam Bradford passes to Chris Givens runs for a 2 Pt. Conversion). Drive: 14 plays, 84 yards in 4:07. | |
| 4th Quarter | |
| 3-10-BUF 28 | (1:07) (Shotgun) S.Bradford pass short left to B.Gibson ran ob at BUF 13 for 15 yards. Caught along sideline at BUF 13. |
| 1-10-BUF 13 | (:58) (Shotgun) S.Bradford pass incomplete short middle to L.Kendricks (M.Dareus). Pass batted at line. |
| 2-10-BUF 13 | (:54) (Shotgun) S.Bradford pass short middle to B.Gibson for 13 yards, TOUCHDOWN. Caught 8 yds. into end zone, slanting from left. |
| (Pass formation) TWO-POINT CONVERSION ATTEMPT. S.Bradford pass to C.Givens is complete. ATTEMPT SUCCEEDS. | |
| G.Zuerlein kicks 64 yards from SL 35 to BUF 1. B.Smith to BUF 23 for 22 yards (D.Stewart). | |
| 1-10-BUF 23 | (:42) (Shotgun) R.Fitzpatrick pass deep right to S.Chandler to BUF 42 for 19 yards (D.Stewart). Caught at BUF 41, slanting from middle. |
| 1-10-BUF 42 | (:34) (Shotgun) R.Fitzpatrick pass incomplete deep left to T.Graham (J.Jenkins). Receiver and coverage at SL 20. |
| 2-10-BUF 42 | (:28) (Shotgun) R.Fitzpatrick sacked at BUF 33 for -9 yards (R.Quinn). |
| 3-19-BUF 33 | (:21) (Shotgun) R.Fitzpatrick pass short right intended for T.Graham INTERCEPTED by J.Dunbar [W.Hayes] at BUF 48. J.Dunbar to BUF 27 for 21 yards (S.Chandler). |
| 1-10-BUF 27 | (:12) S.Bradford kneels to BUF 28 for -1 yards. |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| R. Fitzpatrick | 25/33 | 247 | 1 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| C. Spiller | 7 | 37 | 0 | 13 |
| F. Jackson | 9 | 14 | 0 | 14 |
| T. Graham | 1 | 5 | 0 | 5 |
| R. Fitzpatrick | 3 | 5 | 0 | 3 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| S. Johnson | 6 | 71 | 0 | 34 |
| S. Chandler | 5 | 71 | 0 | 23 |
| T. Graham | 3 | 33 | 0 | 16 |
| D. Jones | 3 | 33 | 0 | 19 |
| F. Jackson | 5 | 16 | 0 | 9 |
| C. Spiller | 1 | 15 | 0 | 15 |
| B. Smith | 1 | 6 | 0 | 6 |
| L. Smith | 1 | 2 | 1 | 2 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| F. Jackson | 1 | 1 | 0 | 0 |
| R. Fitzpatrick | 1 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| R. Lindell | 2/2 | 40 | 0/0 | 6 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| S. Powell | 7 | 39.1 | 3 | 55 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. McKelvin | 2 | 28.5 | 0 | 30 |
| B. Smith | 1 | 22.0 | 0 | 22 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| L. McKelvin | 4 | 11.0 | 0 | 19 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Barnett | 7-3 | 0.0 | 0 | 0 |
| J. Byrd | 4-1 | 0.0 | 0 | 0 |
| K. Sheppard | 3-3 | 0.0 | 0 | 0 |
| L. McKelvin | 3-1 | 0.0 | 0 | 0 |
| K. Williams | 3-1 | 0.0 | 0 | 0 |
| B. Scott | 3-0 | 0.0 | 0 | 0 |
| A. Moats | 2-0 | 0.0 | 0 | 0 |
| R. Brooks | 2-0 | 0.0 | 0 | 0 |
| S. Gilmore | 2-0 | 0.0 | 1 | 0 |
| J. Rogers | 2-0 | 0.0 | 0 | 0 |
| G. Wilson | 2-1 | 0.0 | 0 | 0 |
| D. Searcy | 2-3 | 0.0 | 0 | 0 |
| M. Williams | 2-1 | 1.0 | 0 | 1 |
| K. Moore | 1-4 | 0.0 | 0 | 0 |
| D. Snow | 1-0 | 0.0 | 0 | 0 |
| S. Chandler | 1-0 | 0.0 | 0 | 0 |
| A. Carrington | 1-1 | 0.0 | 0 | 0 |
| G. Sanborn | 1-0 | 0.0 | 0 | 0 |
| M. Dareus | 1-1 | 0.0 | 0 | 0 |
| S. Johnson | 1-2 | 0.0 | 0 | 0 |
| B. Smith | 1-0 | 0.0 | 0 | 0 |
| S. Merriman | 0-2 | 0.0 | 0 | 0 |
| N. Bradham | 0-2 | 0.0 | 0 | 0 |
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