| Passing | ||||
| CP/AT | YDS | TD | INT | |
| C. Kaepernick | 14/25 | 216 | 4 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 21 | 83 | 0 | 15 |
| D. Goldson | 1 | 31 | 0 | 31 |
| L. James | 8 | 31 | 0 | 17 |
| C. Kaepernick | 7 | 28 | 0 | 19 |
| A. Dixon | 2 | 7 | 0 | 5 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| M. Crabtree | 7 | 107 | 2 | 38 |
| R. Moss | 2 | 36 | 1 | 24 |
| F. Gore | 2 | 34 | 0 | 26 |
| D. Walker | 2 | 29 | 1 | 34 |
| V. Davis | 1 | 10 | 0 | 10 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| C. Kaepernick | 4 | 0 | 2 | -7 |
| D. Walker | 1 | 1 | 0 | 0 |
| T. Ginn | 1 | 0 | 1 | 0 |
| C. Culliver | 0 | 0 | 1 | 0 |
| F. Gore | 0 | 0 | 2 | 3 |
| D. Goldson | 0 | 0 | 1 | 66 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 2/3 | 28 | 5/5 | 11 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 5 | 56.6 | 3 | 64 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. James | 4 | 33.2 | 0 | 62 |
| D. Walker | 2 | 10.5 | 0 | 18 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 3 | 5.0 | 0 | 8 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Bowman | 9-3 | 0.0 | 0 | 1 |
| T. Brown | 7-1 | 0.0 | 0 | 0 |
| C. Culliver | 6-0 | 0.0 | 0 | 0 |
| D. Whitner | 5-2 | 0.0 | 0 | 1 |
| P. Willis | 5-6 | 0.0 | 0 | 0 |
| D. Goldson | 4-0 | 0.0 | 0 | 0 |
| R. McDonald | 4-0 | 2.0 | 0 | 0 |
| C. Rogers | 3-1 | 0.0 | 1 | 0 |
| R. Jean Francois | 2-0 | 1.0 | 0 | 0 |
| T. Brock | 2-1 | 0.0 | 0 | 0 |
| D. Walker | 1-0 | 0.0 | 0 | 0 |
| J. Smith | 1-1 | 0.0 | 0 | 0 |
| M. Wilhoite | 1-1 | 0.0 | 0 | 0 |
| W. Tukuafu | 1-1 | 0.0 | 0 | 0 |
| L. Grant | 1-0 | 0.0 | 0 | 0 |
| B. Miller | 1-1 | 0.0 | 0 | 0 |
| D. McBath | 0-1 | 0.0 | 0 | 0 |
| A. Dixon | 0-1 | 0.0 | 0 | 0 |
| A. Smith | 0-1 | 0.0 | 1 | 0 |
| A. Brooks | 0-1 | 0.0 | 0 | 0 |
| C. Spillman | 0-1 | 0.0 | 0 | 0 |
| P. Cox | 0-1 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| San Francisco | 7 | 10 | 14 | 10 |
| New England | 0 | 3 | 7 | 24 |
| 1st Quarter | ||
| TD @ 10:55 | Randy Moss catches a 24 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 6 plays, 63 yards in 2:40. | |
| 2nd Quarter | ||
| FG @ 8:31 | Stephen Gostkowski makes a 32 yard kick. Drive: 16 plays, 62 yards in 6:24. | |
| TD @ 6:59 | Delanie Walker catches a 34 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 3 plays, 80 yards in 1:32. | |
| FG @ 0:00 | David Akers makes a 20 yard kick. Drive: 15 plays, 76 yards in 6:04. | |
| 3rd Quarter | ||
| TD @ 10:38 | Frank Gore makes a 3 yard fumble return (David Akers kick is good). | |
| TD @ 10:21 | Michael Crabtree catches a 27 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 1 play, 27 yards in 0:05. | |
| TD @ 5:59 | Danny Woodhead runs for 6 yards (Stephen Gostkowski kick is good). Drive: 13 plays, 73 yards in 4:22. | |
| 4th Quarter | ||
| TD @ 14:58 | Tom Brady runs for 1 yard (Stephen Gostkowski kick is good). Drive: 9 plays, 86 yards in 3:41. | |
| TD @ 12:13 | Aaron Hernandez catches a 5 yard pass from Tom Brady (Stephen Gostkowski kick is good). Drive: 6 plays, 66 yards in 1:04. | |
| TD @ 6:43 | Danny Woodhead runs for 1 yard (Stephen Gostkowski kick is good). Drive: 7 plays, 92 yards in 3:13. | |
| TD @ 6:25 | Michael Crabtree catches a 38 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 1 play, 38 yards in 0:18. | |
| FG @ 1:56 | David Akers makes a 28 yard kick. Drive: 4 plays, 2 yards in 0:24. | |
| FG @ 0:38 | Stephen Gostkowski makes a 41 yard kick. Drive: 11 plays, 57 yards in 1:18. | |
| 4th Quarter | |
| 3-3-NE 39 | (1:27) (No Huddle, Shotgun) T.Brady pass incomplete short left to B.Lloyd. |
| 4-3-NE 39 | (1:24) (No Huddle, Shotgun) T.Brady pass short right to D.Branch to NE 47 for 8 yards (C.Culliver). |
| 1-10-NE 47 | (1:08) (No Huddle) T.Brady spiked the ball to stop the clock. |
| 2-10-NE 47 | (1:08) (No Huddle, Shotgun) T.Brady pass short right to D.Woodhead ran ob at SF 47 for 6 yards. |
| 3-4-SF 47 | (1:04) (No Huddle, Shotgun) T.Brady pass incomplete deep left to B.Lloyd. |
| 4-4-SF 47 | (:58) (No Huddle, Shotgun) T.Brady pass deep middle to B.Lloyd to SF 23 for 24 yards (T.Brown). |
| 1-10-SF 23 | (:43) (No Huddle) T.Brady spiked the ball to stop the clock. |
| 2-10-SF 23 | (:43) S.Gostkowski 41 yard field goal is GOOD, Center-D.Aiken, Holder-Z.Mesko. |
| (Onside Kick formation) S.Gostkowski kicks onside 14 yards from NE 35 to NE 49. D.Walker to NE 46 for 3 yards (B.Bolden). | |
| 1-10-NE 46 | (:36) C.Kaepernick kneels, dead ball declared at NE 47 for -1 yards. |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| T. Brady | 36/65 | 443 | 1 | 2 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| D. Woodhead | 12 | 61 | 2 | 15 |
| S. Ridley | 9 | 23 | 0 | 9 |
| T. Brady | 3 | 11 | 1 | 5 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| B. Lloyd | 10 | 190 | 0 | 53 |
| A. Hernandez | 10 | 92 | 1 | 20 |
| W. Welker | 5 | 56 | 0 | 15 |
| M. Hoomanawanui | 1 | 41 | 0 | 41 |
| D. Branch | 4 | 37 | 0 | 13 |
| D. Woodhead | 5 | 23 | 0 | 7 |
| S. Vereen | 1 | 4 | 0 | 4 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| S. Ridley | 1 | 1 | 0 | 0 |
| S. Vereen | 1 | 1 | 0 | 0 |
| A. Talib | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| S. Gostkowski | 2/2 | 41 | 4/4 | 10 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| Z. Mesko | 5 | 45.6 | 1 | 49 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| D. McCourty | 5 | 21.4 | 0 | 26 |
| M. Slater | 1 | 0.0 | 0 | 0 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| W. Welker | 5 | 2.6 | 0 | 11 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| D. Hightower | 5-3 | 0.0 | 0 | 0 |
| J. Mayo | 5-7 | 0.0 | 0 | 0 |
| B. Spikes | 3-3 | 0.0 | 0 | 0 |
| J. Francis | 2-2 | 0.0 | 0 | 0 |
| D. McCourty | 2-1 | 0.0 | 1 | 0 |
| M. Slater | 2-1 | 0.0 | 0 | 0 |
| K. Arrington | 2-0 | 0.0 | 0 | 0 |
| C. Jones | 2-0 | 0.0 | 0 | 0 |
| A. Talib | 2-2 | 0.0 | 0 | 0 |
| R. Ninkovich | 2-5 | 1.0 | 0 | 0 |
| N. Ebner | 1-0 | 0.0 | 0 | 0 |
| T. Brady | 1-0 | 0.0 | 0 | 0 |
| M. Cole | 1-0 | 0.0 | 0 | 0 |
| A. Dennard | 1-0 | 0.0 | 0 | 0 |
| K. Love | 1-2 | 0.0 | 0 | 0 |
| N. Solder | 1-0 | 0.0 | 0 | 0 |
| P. Chung | 1-3 | 0.0 | 0 | 0 |
| W. Welker | 1-0 | 0.0 | 0 | 0 |
| S. Vollmer | 1-0 | 0.0 | 0 | 0 |
| S. Gregory | 1-1 | 0.0 | 0 | 1 |
| B. Bolden | 1-0 | 0.0 | 0 | 0 |
| A. Hernandez | 1-0 | 0.0 | 0 | 0 |
| V. Wilfork | 0-3 | 0.0 | 0 | 0 |
| T. Scott | 0-1 | 0.0 | 0 | 0 |
| M. Hoomanawanui | 0-1 | 0.0 | 0 | 0 |
| B. Deaderick | 0-1 | 0.0 | 0 | 0 |
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