Williams is slated to undergo season-ending left knee surgery, ESPN.com reports.
Williams, who hasn't played since Oct. 18, has been slow to recover from a meniscus injury and will thus turn to a procedure that should enable him to return to the playing field well in advance of the 2016 season.
Amendola (knee) will not play Sunday against the Broncos, Tom Curran of CSN Northeast reports.
As of Friday night, there was still a chance Amendola would make the trip to Denver with the team, but after being evaluated Saturday, the receiver has been ruled out and will remain back in Foxboro. Amendola suffered the knee injury against the Bills on Monday, and he was limited in practice Thursday and Friday after not participating on Wednesday. With Julian Edelman (foot) out and Aaron Dobson, Brian Tyms, Josh Boyce and Brandon Gibson all on IR, the Pats are currently left with only three healthy receivers heading into Sunday: Brandon LaFell, Chris Harper and KeShawn Martin. All three figure to see expanded roles, with tight end Rob Gronkowski likely seeing even more attention than usual from the Denver defense.
Three injured players have been placed on the inactive list by the Patriots for their season opener Thursday night against Pittsburgh. They are running back Travaris Cadet (hamstring), defensive lineman Trey Flowers (knee) and safety Tavon Wilson (quad).
Edelman underwent foot surgery Monday on the Jones fracture he suffered Sunday against the Giants, and he could return in 6-to-8 weeks, according to Albert Breer of NFL Network.
Breer notes that the recovery timeframe is a rough one, so while it could theoretically allow Edelman to return during the postseason, it's certainly no guarantee. Danny Amendola is expected to get an increase in offensive snaps with Edelman sidelined, while Brandon LaFell, Aaron Dobson and Rob Gronkowski could all see more targets as well.
Jones (abdomen) was on the field for 63 of the Patriots' 71 defensive snaps in Monday's win over the Bills, ESPN's Mike Reiss reports.
Per the report, Jones had a chance to rack up a sack Monday, but QB Tyrod Taylor slipped out of the defensive end's grasp, with Jones thus limited to one tackle in the game. Through 10 games overall, Jones has notched 31 tackles and 10.5 sacks.
Martin (hamstring) is expected to be active for Sunday night's game against the Broncos, ESPN's Adam Schefter reports.
With Julian Edelman out with a foot injury, Aaron Dobson on IR and Danny Amendola having been ruled out this week, there's an opportunity for Martin (assuming he suits up) to step into a key role in the Patriots' Week 12 offense along with fellow wideout Brandon LaFell and possibly Chris Harper, though the Broncos -- who have allowed a league-low average of 190.6 passing yards per game to date -- present them all with a less than optimal matchup, in chilly and possibly snowy conditions in Denver.