Pierce (calf) is inactive for Thursday's game against the Titans, Ryan O'Halloran of the Florida Times-Union reports.
Pierce likely suffered his injury on special teams during Sunday's win over the Ravens, as he didn't get any offensive snaps. In Pierce's absence, Toby Gehart (groin) will serve as the No. 3 running back.
Wide receiver Justin Blackmon , who hasn't practiced or played since 2013 after being suspended for the third time for violating the NFL's substance abuse policy, is unlikely to return to the Jaguars according to GM David Caldwell, per ESPN.com.
Taylor (right shoulder) was limited at practice Wednesday, ESPN's Mike Rodak reports.
Per Rodak, Taylor relayed that he rested his shoulder Wednesday, but plans to resume throwing at Thursday's practice. Assuming that occurs without any setbacks, we'd expect the QB to remain on course to be able to play Sunday against the Chiefs.
Clay, who left Monday's game against the Patriots for a time with a neck issue, is not listed on the Bills' Week 12 injury report.
Coming off a one-catch, 14-yard effort on three Week 11 targets, Clay is a speculative play Sunday against the Chiefs, a team that has reeled off four straight wins and held San Diego tight ends Ladarius Green and Antonio Gates to a combined two catches for 15 yards this past weekend.
Coach Rex Ryan says Williams (knee) has a 50-50 chance to return this season.
Williams is a Pro Bowl player and he's always been worth every bit of those honors, so it'd be a big loss for the defense if he's unable to return this season. Fortunately, the Bills have three other very capable and healthy linemen in Marcell Dareus, Mario Williams, and Jerry Hughes, though it looks like the hope of the foursome being the league's best this season may be fading thanks to Kyle Williams' injury.
Williams left Monday's game against the Patriots early due to a foot injury, so it remains to be seen if the former first-round pick will be able to practice at all this week. He's recorded just 14 tackles and three sacks in 10 games this season, so his absence will likely affect the Bills' defensive line depth more than IDP owners.