A big-time pitching matchup unfolds on Wednesday when the Baltimore Orioles (57-34) host the Chicago Cubs (43-49). Righty Corbin Burnes (9-3, 2.32 ERA) is on the hill for Baltimore, while Chicago will send lefty Shota Imanaga (7-2, 3.16 ERA) to the mound. The Cubs won Game 1 of the series on Tuesday despite being listed as +159 underdogs on the money line in that one.  

First pitch is 6:35 p.m. ET at Oriole Park at Camden Yards. The latest Cubs vs. Orioles odds via SportsLine consensus list Baltimore as the -182 favorite (risk $182 to win $100). The over/under is 8.5. Before making any Orioles vs. Cubs picks, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 16 of the 2024 MLB season a profitable 49-37 on all-top rated MLB picks this season. Dating back to last season, it is on a 24-9 roll on top-rated run-line picks (+1077). Anybody following has seen strong returns. 

Now, the model has set its sights on Orioles vs. Cubs and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Cubs vs. Orioles:

  • Orioles vs. Cubs money line: Orioles -182, Cubs +151
  • Orioles vs. Cubs run line: Orioles -1.5 (+116) 
  • Orioles vs. Cubs over/under: 8.5 runs
  • Orioles vs. Cubs picks: See picks at SportsLine

Top Cubs vs. Orioles pick

For Orioles vs. Cubs, one of the top picks from SportsLine's model is that Cubs outfielder Ian Happ goes over 0.5 total bases (-154). The model is projecting 1.3 total bases for Happ and rates this as a five-star pick, which is its maximum confidence rating. 

Happ is red-hot in July, batting .417 with an .875 slugging percentage and a whopping 1.375 OPS. He's recorded at least one hit in five of his last six games. Burnes presents a tough matchup, but Happ has seen him plenty of times dating back to when Burnes pitched for the Brewers in the NL Central.

Happ has a career .292 average and an OPS of .935 against Burnes, so the model is confident that he'll be able to record at least a base hit in this one, making it one of the top Cubs vs. Orioles prop picks. See more picks at SportsLine

How to make Orioles vs. Cubs picks

In addition to that prop pick, the model also says one side of the money line has all the value. You can only get the MLB model's picks and analysis at SportsLine.

So who wins Cubs vs. Orioles, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that's 49-37 on top-rated MLB picks, and find out.