The Iowa Hawkeyes face a significant challenge on Saturday afternoon in Big Ten action. Iowa hosts the No. 4 Michigan Wolverines in the first battle between the clubs in Iowa City since 2016. Iowa is 3-1 overall and 1-0 in conference action this season amid offensive struggles. Michigan is 4-0 overall and 1-0 in the Big Ten, with the most recent meeting between the clubs ending in a 42-3 win by the Wolverines in the Big Ten championship game.

Caesars Sportsbook lists the Wolverines as 10.5-point road favorites for this noon ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 42 in the latest Michigan vs. Iowa odds. Before making any Iowa vs. Michigan picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan vs. Iowa and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Iowa vs. Michigan:

  • Michigan vs. Iowa spread: Michigan -10.5
  • Michigan vs. Iowa over/under: 42 points
  • Michigan vs. Iowa money line: Michigan -440, Iowa +335
  • MICH: The Wolverines are 2-2 against the spread in the last four games
  • IOWA: The Hawkeyes are 2-1 against the spread in the last three games
  • Michigan vs. Iowa picks: See picks at SportsLine

Why Michigan can cover

Michigan is averaging 50.0 points per game this season, No. 2 in FBS, and no team in the country has more rushing touchdowns (17) than the Wolverines. Michigan is also generating almost 500 total yards per game, and the duo of quarterback JJ McCarthy and running back Blake Corum is lighting it up in 2022. From there, Michigan's defense has an encouraging projection in Saturday's game, in part due to Iowa's weaknesses. The Hawkeyes have the worst scoring average (17.0 points per game) of any Big Ten team this season, and Iowa is No. 120 in FBS in scoring offense. Iowa is also last in FBS with 232.5 total yards per game, and Hawkeyes quarterback Spencer Petras is completing only 51% of his passes. 

Michigan is giving up only 6.7 points per game in the last three meetings against Iowa, and the Wolverines are near the top of the country in myriad defensive categories this season. Michigan is No. 7 in points allowed (11.0 per game), No. 8 in yards per play allowed (3.9), No. 6 in yards allowed (244.8 per game), No. 4 in passing yards allowed (135.8 per game) and yards per pass attempt allowed (4.7). Opponents have been sacked 11 times in four games against Michigan, with 3.2 yards per carry and clear struggles to move the ball.

Why Iowa can cover 

Kinnick Stadium has been a house of horrors for Michigan in recent years, with Iowa winning the last four games against the Wolverines at home. In addition, Michigan played one of the easiest schedules in FBS across the first three weeks of the season and, while the Wolverines defeated Maryland last week, Michigan gave up 397 total yards and won by only a single score. Iowa's defense is also elite by the metrics, including a nation-leading mark of 5.8 points allowed per game. 

The Hawkeyes have allowed 10 points or fewer in every game this season, with Iowa's defense giving up only two total touchdowns and 236.3 total yards per game. Iowa is leading the country with 4.6 yards allowed per pass attempt, and the Hawkeyes are giving up only 2.2 yards per carry. Iowa has not allowed a rushing touchdown all season, and Kirk Ferentz's program has five interceptions and 12 sacks already in 2022.

How to make Iowa vs. Michigan picks

SportsLine's model is leaning Over the total, projecting 49 combined points. It has also generated an against the spread pick that hits in almost 60% of simulations. You can only get the model's pick at SportsLine

So who wins Michigan vs. Iowa? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that finished the past six-plus years up more than $3,100 on its FBS college football picks, and find out.