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Patrick Mahomes will become just the third quarterback in NFL history to start in five different Super Bowls when the Kansas City Chiefs take on the Philadelphia Eagles in Super Bowl 59. Mahomes' experience will likely help him elevate his teammates, which you should certainly consider before locking in your Super Bowl 59 NFL DFS lineups. Many of the Eagles' key playmakers aren't playing in their first Super Bowl either with Jalen Hurts, A.J. Brown and DeVonta Smith all members of the Eagles team that lost to the Chiefs in 2023. With so many veteran playmakers set to take the field, how should you craft your Super Bowl LIX NFL DFS strategy to create a winning lineup? 

Mahomes averaged 245.5 passing yards per game this year, the lowest of his seven years as a starting quarterback. He's averaging even fewer passing yards (211 per game) in the postseason, yet the Chiefs won 17 of the 18 games he started this year, including the postseason. Should Mahomes be featured in your 2025 Super Bowl NFL DFS picks, or should you look elsewhere for value? Before making any NFL DFS picks for Eagles vs. Chiefs in Super Bowl 59 or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine's advanced NFL DFS Lineup Optimizer.

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.

Now, SportsLine's NFL DFS Optimizer has turned its attention to the 2025 Super Bowl between the Chiefs vs. Eagles and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL DFS picks for Super Bowl 59

One of the Optimizer's top DFS value picks for Sunday is Eagles running back Saquon Barkley. He was named NFL Offensive Player of the Year for his work during the regular season when he eclipsed 2,000 rushing yards, but Barkley has, arguably, been even better in the postseason. He's averaging 147.3 rushing yards across the three playoff games and has scored five touchdowns. Barkley has 118-plus rushing yards in each of his last five games and gets to face a Chiefs defense which has been gashed by running backs recently.

After allowing just two running backs in the regular season to reach 100-plus scrimmage yards, the Chiefs have allowed two to do so across their pair of postseason contests. Joe Mixon had 100 all-purpose yards and a touchdown in the Divisional Round, before James Cook had 134 yards and two scores in the AFC Championship Game. Neither of those players are at the level of Barkley, who is averaging 133.6 scrimmage yards with seven total touchdowns across his five-game postseason career. Barkley won't come cheaply for NFL DFS lineups, but his production will warrant his price tags for Super Bowl Sunday. See who else to pick here.

The Optimizer's NFL DFS strategy also includes rostering Eagles tight end Dallas Goedert. The 30-year-old has been a consistent, reliable, high-floor option for daily Fantasy football players making postseason NFL DFS lineups over the last few years. Goedert has at least 50 yards or a touchdown in eight of his last nine postseason games. He is averaging five receptions for 62.7 yards per game this postseason, which is the second-most receptions and third-most receiving yards per game of anyone playing in this year's Super Bowl. 

Tight ends have found success against Kansas City lately. That bodes well for Goedert, who has been targeted 18 times thus far in the postseason, hauling in 15 catches for 188 yards and a touchdown. Now, Goedert and the Eagles will take on a Chiefs defense that gave up 218.8 passing yards per game during the regular season, which ranked in the bottom half of the NFL. Lock him in your NFL DFS lineups and look for a big return against Kansas City. You can see the rest of the Optimizer's NFL DFS picks here.

How to build 2025 Super Bowl NFL DFS lineups for Chiefs vs. Eagles

The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers for Super Bowl 59. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the Optimizer's NFL DFS picks, at SportsLine

So what is the optimal NFL DFS lineup for Eagles vs. Chiefs in Super Bowl 59, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS Optimizer that simulates every game 10,000 times, and find out.