bo-nix-denver-broncos
Imagn Images

The Week 16 NFL schedule features 16 more games, including several with potential playoff ramifications. One such game is an NFC North battle between the Green Bay Packers (9-4-1) and the Chicago Bears (10-4). Green Bay is favored by 1.5 points as Jordan Love and the Packers face Caleb Williams and the Bears. Green Bay has won nine of the past 10 meetings with Chicago, including a 28-21 win at Lambeau Field two weeks ago. Another key matchup between two NFC contenders is the NFC South matchup between the division co-leading Carolina Panthers and Tampa Bay Buccaneers. The teams are tied with 7-7 records, and play each other two times in the final three weeks. 

The Buccaneers enter as 2.5-point road favorites. Sunday's largest spreads include Raiders vs. Texans (-14.5), Bills (-10) vs. Browns, Steelers vs. Lions (-7) and Eagles (-6) vs. Commanders. Among the worst injuries suffered in Week 15 include Patrick Mahomes (knee) of the Chiefs and Micah Parson (knee) of the Packers. Before making any Week 16 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. 

For Week 16 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 16 NFL schedule here.

Top Week 16 NFL AI picks

After analyzing every game in Week 16, the AI says the Broncos (-3, 45.5), who have won 11 in a row, cover comfortably against the Jaguars. 

The Broncos have gone over in each of their last four games, while the over has hit in each of the last two Jaguars games. Bet the Over 45.5 in the latest DraftKings promo code, which offers $200 in bonus bets if your first bet wins:

Denver is looking for its 12th win in a row and is expected to win comfortably over the AFC South-leading Jaguars. A win will move the Broncos closer to clinching the AFC West title. SportsLine AI rates the Broncos as an A+ spread pick and also predicts a 27-20 win on average. See its other Week 16 football predictions and football picks at SportsLine, and bet the Broncos at DraftKings here:

How to make Week 16 NFL picks

In addition, the AI PickBot has generated more than two dozen highly-coveted A picks for Week 16. You need to see the AI's NFL picks before making any Week 16 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 16 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.