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The NFL Week 17 schedule features a full slate of games, including 10 on Sunday, several of which have a direct bearing on the NFL playoffs and seeding. In the NFC, the NFC West-leading Seattle Seahawks take on the NFC South-leading Carolina Panthers. Seattle enters as a 7.5-point favorite at DraftKings Sportsbook. In the AFC South, the division-leading Jacksonville Jaguars take on the Indianapolis Colts. The Jaguars are favored by 6.5 points. Sunday's largest spread is Patriots (-13.5) vs. Jets, while another larger spread is on 'Monday Night Football,' with the Rams (-8.5) vs. Falcons. 

The smallest spreads Sunday include Giants vs. Raiders (-1.5), Saints (-2.5) vs. Titans, Eagles vs. Bills (-2.5) and Bears vs. 49ers (-2.5) on 'Sunday Night Football.' Seattle entered the weekend as the NFC's top seed, while Denver was first in the AFC. Before making any Week 17 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. 

For Week 17 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 17 NFL schedule here.

Top Week 17 NFL AI picks

After analyzing every game in Week 17, the AI says the Steelers (-3.5, 34), who have won three in a row, cover comfortably against the Browns. 

The Steelers have gone over in two of their last three games, while the over has hit in six of the past 10 Browns games. Bet the Over 34.5 in the latest DraftKings promo code, which offers $200 in bonus bets if your first bet wins:

Pittsburgh is looking to win its first AFC North title since 2020 and is expected to win comfortably over the division-rival Browns. A win would be their third in a row over Cleveland. SportsLine AI rates the Steelers as an A+ spread pick and also predicts a 24-15 win on average. See its other Week 17 football predictions and football picks at SportsLine, and bet the Steelers at DraftKings here:

How to make Week 17 NFL picks

In addition, the AI PickBot has generated more than two dozen highly-coveted A picks for Week 17. You need to see the AI's NFL picks before making any Week 17 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 17 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.