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The NFL playoff picture will begin to crystalize as the NFL continues the Week 17 schedule. The NFC West already has three teams that have qualified for the playoffs, but seeding remains on the line with two weeks remaining. The top seed in the AFC is also at stake, making sure to provide excitement with several pivotal contests.

There are a number of solid matchups on the Week 17 NFL schedule, including several on Sunday, including Seahawks (-7) vs. Panthers, Steelers (-3) vs. Browns, Jaguars (-6) vs. Colts, Eagles vs. Bills (-1.5) and Bears vs. 49ers (-3) and a 'Monday Night Football' matchup in Rams (-8) vs. Falcons. Before locking in any Week 17 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 16 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of over 25-1. You can only see the model's Week 17 NFL picks at SportsLine.

Top Week 17 NFL picks

After simulating every game 10,000 times, the model is high on the Pittsburgh Steelers (-3, 34.5) to cover against the Cleveland Browns on Sunday afternoon. Bet our Steelers vs. Browns SGP at DraftKings below, and see our 25-1 Week 17 NFL parlay at SportsLine.

The Steelers are led by quarterback Aaron Rodgers. In 14 games this season, he has completed 66.7% of his passes for 2,860 yards and 23 touchdowns with seven interceptions and an 98.2 rating. He has also rushed 19 times for 35 yards (1.8 average) and one score. In Sunday's 29-24 win over the Detroit Lions, he completed 27 of 41 passes for 266 yards and one touchdown.

The model has Pittsburgh winning outright nearly 70% of the time and covering in nearly 60% of simulations in a B-rated spread pick. See which other NFL parlay picks to make here.

How to make Week 17 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will easily cover. You can only see the model's Week 17 NFL best bets and NFL parlay at SportsLine.

What are the model's top Week 17 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 17 NFL best bets from a model on a 53-37 run on top-rated picks, and find out.