NFL: Los Angeles Rams at Carolina Panthers
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The Carolina Panthers fired head coach Matt Rhule on Monday, making him the first head coach fired in the 2022 season. The Panthers dumped Rhule after a 1-4 start and an 11-27 record overall in three seasons and will now turn to former Cardinals head coach Steve Wilks in the interim ahead of a Week 6 matchup with the Los Angeles Rams. The defending Super Bowl champions are off to a disappointing 2-3 start and have only managed 19 points the last two weeks in losses to the Cowboys and 49ers.

Kickoff is scheduled for 4:05 p.m. ET at SoFi Stadium. Los Angeles is favored by 10 points in the latest Panthers vs. Rams odds from Caesars Sportsbook, while the over/under is set at 41.5. Before entering any Rams vs. Panthers picks, you'll want to see the NFL predictions from the advanced computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Rams vs. Panthers. You can head to SportsLine to see its picks. Here are several NFL betting lines for Panthers vs. Rams:

  • Rams vs. Panthers spread: Rams -10
  • Rams vs. Panthers over/under: 41.5 points
  • Rams vs. Panthers picks: See picks here

What you need to know about the Rams

The Rams came up short against the Dallas Cowboys this past Sunday, falling 22-10. One thing holding Los Angeles back was the mediocre play of QB Matthew Stafford, who did not have his best game: despite one touchdown, he threw one interception and fumbled the ball twice.

Los Angeles has now scored 10 points or fewer in three of their five games this season and rank last in the NFL in yards per play. However, the defense still has potential future Hall of Famers at every level with Aaron Donald on the defensive line, Bobby Wagner at linebacker and Jalen Ramsey in the secondary. Donald continues to be one of the game's biggest defensive threats and enters Week 6 with six tackles for loss, six quarterback hits, four sacks, a forced fumble and a fumble recovery.

What you need to know about the Panthers

Carolina hasn't stopped with firing Rhule as the organization shifts. The Panthers also made the decision to start P.J. Walker on Sunday against the Rams. The Temple product and former XFL star is 2-0 in his career as a starter, leading the Panthers to a 20-0 win over the Lions in Week 11 of the 2020 season and a 34-10 win over the Cardinals in Week 10 of the 2021 season.

Walker completed 73.0 percent of his passes in those two starts and went 5-for-6 for 60 yards while leading one of Carolina's most successful drives of the day last week against the 49ers in relief of Baker Mayfield. The hope is that Walker can inject some life in this Panthers offense and hopefully create enough balance to get Christian McCaffrey going. He produced 209 scrimmage yards and two touchdowns in his last meeting with the Rams in 2019.

How to make Panthers vs. Rams picks

The model has simulated Rams vs. Panthers 10,000 times and the results are in. The model is leaning Over and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Rams vs. Panthers? And which side of the spread has all the value? Visit SportsLine right now to find out which side of the Panthers vs. Rams spread you should be all over, all from the model on a 146-106 roll on its top-rated NFL picks, and find out.