Week 16 NFL odds, lines, best bets, predictions: Computer model backing Ravens and Chiefs
SportsLine's advanced model has locked in its NFL bets today from 10,000 simulations
The Week 16 NFL schedule sees a number of teams playing their final home games of the regular season. Thus, there's nearly a full year's worth of home games to gather NFL betting trends from in order to help with Week 16 NFL picks. Two of those teams with their final home stands include the Ravens, who are -2.5 versus the Patriots, as well as the Cardinals who are +2.5 versus the Falcons. Both Baltimore and Arizona have a league-high of six ATS home losses this year, perhaps, making them ones to fade with Week 16 NFL predictions.
There are more road favorites than home teams giving points, according to the Week 16 NFL odds. Amongst those home dogs are Giants (+2.5) versus the Vikings, the Panthers (+2.5) against the Bucs and the Titans (+3.5) against a Chiefs squad that lost Patrick Mahomes to a torn ACL. All of the updated Week 16 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 16 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, it has turned its attention to the latest Week 16 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
Top Week 16 NFL predictions
We can tell you one of the model's strongest Week 16 NFL picks is that the Ravens (-2.5, 48.5) cover versus New England on Sunday night. Baltimore is coming off a dominant 24-0 win over Cincinnati, while the Patriots saw their 10-game win streak come to an end at the hands of Buffalo. The Pats have now dropped two of their last three versus the spread, as the team allowed season highs in points (35) and rushing yards (168) in the defeat to the Bills. Now, New England has to face the league's No. 3 rushing offense, led by Derrick Henry and Lamar Jackson, and the quarterback has a stunning 16-0 regular season record in Week 15 or later. Baltimore is projected to rush for over 170 yards, which allows the Ravens to cover versus the spread 60% of the time. See which other teams to pick here, and bet the Ravens using the DraftKings promo code, which offers $200 in bonus bets if your bet wins right here:
Another one of its Week 16 NFL predictions: the Chiefs (-3.5, 37.5) cover versus the Titans in well over 50% of simulations in a Sunday kickoff at 1 p.m. ET. Patrick Mahomes' (torn ACL) injury shifted this line a full touchdown from Chiefs -10.5, but Kansas City still has a more complete team in just about all regards than Tennessee. While the Chiefs' No. 20 rushing offense isn't great, it's miles ahead of Tennessee's No. 30 ground attack. Then on defense, Kansas City boasts top 10 rankings in both points allowed and yards allowed, while the Titans rank in the bottom six in both categories. Tennessee is only 3-12 ATS over its last 15 home games and just allowed both its second-most total yards (430) and passing yards (292) of the year to San Fran on Sunday, so Gardner Minshew should be able to find success. The model also says the Under hits well over 50% of the time. See which other teams to pick here, and bet the Chiefs to cover at DraftKings:
How to make Week 16 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 16 NFL schedule and just revealed four A-rated picks with the spread and total, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what Week 16 NFL picks can you make with confidence, and which four picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 16 NFL betting odds, lines, live spreads, scores
Get Week 16 NFL picks at SportsLine
| Game | Spread | Total | Picks |
| Rams at Seahawks (Thursday) | LAR -1.5 | 44.5 | SEE PICKS HERE |
| Eagles at Commanders (Saturday) | PHI -6 | 45.5 | SEE PICKS HERE |
| Packers at Bears (Saturday) | GB -1.5 | 46.5 | SEE PICKS HERE |
| Buccaneers at Panthers | TB -3 | 45.5 | SEE PICKS HERE |
| Bills at Browns | BUF -10 | 42.5 | SEE PICKS HERE |
| Chargers at Cowboys | DAL -2.5 | 49.5 | SEE PICKS HERE |
| Jets at Saints | NO -4 | 40 | SEE PICKS HERE |
| Vikings at Giants | MIN -2.5 | 44 | SEE PICKS HERE |
| Chiefs at Titans | KC -3.5 | 37.5 | SEE PICKS HERE |
| Bengals at Dolphins | MIA -1.5 | 50.5 | SEE PICKS HERE |
| Falcons at Cardinals | ATL -2.5 | 47.5 | SEE PICKS HERE |
| Jaguars at Broncos | DEN -3 | 45.5 | SEE PICKS HERE |
| Steelers at Lions | DET -7 | 49.5 | SEE PICKS HERE |
| Raiders at Texans | HOU -14.5 | 37.5 | SEE PICKS HERE |
| Patriots at Ravens | BAL -2.5 | 48.5 | SEE PICKS HERE |
| 49ers at Colts (Monday) | SF -5.5 | 46.5 | SEE PICKS HERE |
