Meadows was removed from Sunday's Grapefruit League game against the Pirates after experiencing quadriceps tightness in both of his legs, Marc Topkin of the Tampa Bay Times reports.
The Rays will likely wait and see how Meadows responds to treatment in the next day or two before his availability (or lack thereof) for Opening Day becomes more apparent. Meadows is off to a 6-to-24 start to spring training, with both of his extra-base hits falling in for doubles.