Indians vs. White Sox odds: MLB picks, predictions from advanced computer model

The first full week of the 2019 MLB schedule begins Monday, and the there's only one game in the mid-afternoon time slot as the Chicago White Sox travel to Progressive Field to take on the Cleveland Indians at 4:10 p.m. ET. Both sides are off to a 1-2 start this season, and the latest Indians vs. White Sox odds list Cleveland as the -168 favorite on the money line (risk $168 to win $100), with the over-under for total runs set at 7.5. It's the home opener for Cleveland, but Chicago backers would be in for a big return if the White Sox can pull off the stunner. Before locking in any Indians vs. White Sox picks of your own, be sure to see the MLB predictions from the projection model at SportsLine. 

This model, which simulates every game 10,000 times, has raked in the winnings for those following its picks. The model has a proven track record of hitting its top picks in football, basketball, hockey and more. Anyone who has followed it is way up.

Now, the model has zeroed in on Indians vs. White Sox. We can tell you it is leaning over, and it also says one side of the money line has all the value. You can only see that pick at SportsLine.

The model has taken into account that, if 2018 is any indication, the Indians have several substantial advantages in this matchup. They went a whopping 14-5 against the White Sox last year and boasted a strong 49-32 record at Progressive Field. 

In addition to having the energy of a home-opener crowd, the Indians will send Mike Clevinger to the hill, who is coming off an extremely strong 2018 season. He recorded a 3.02 ERA and a 1.16 WHIP, both career bests. He also took a step forward with his control, walking just 67 batters in 200 innings while striking out 207. He's backed by a lineup with big bats including Jose Ramirez, Hanley Ramirez and Carlos Santana.

But Chicago has some exciting young players in its lineup and is coming off a 6-3 win over the Athletics, making it a potential upset pick on the Indians vs. White Sox money line. 

Super-prospect Eloy Jimenez is the face of Chicago's rebuilding process, and he's getting a shot to play on a regular basis. The consensus top-five prospect in all of Major League Baseball hit .337 with 22 home runs in the minors last season and tallied his first hits in the opening series against the Royals.

Chicago is hoping to see the type of impact from him that the Braves saw from Ronald Acuna, or what the Nationals received from Juan Soto. If he can provide power for the South-Siders, and they have a solid outing from veteran righty Ivan Nova, who walked just 35 batters in 161 innings last year, Chicago could pull off the upset on Monday afternoon, especially with Francisco Lindor (ankle) out for Cleveland. 

So who wins White Sox vs. Indians? And which side of the money line is a must-back? Visit SportsLine now to see which side of the White Sox vs. Indians money line to jump on Monday, all from the advanced model that simulates every MLB game 10,000 times, and find out.

Our Latest Stories