The Denver Broncos will take on the Indianapolis Colts at 1 p.m. ET on Sunday at Lucas Oil Stadium. Indianapolis is 4-2 overall and 2-1 at home, while Denver is 2-5 overall and 1-2 on the road. The Colts are ranked first in the AFC South, while Denver is ranked third in the AFC West. The Colts are coming off an impressive 30-23 victory over the Houston Texans, while the Broncos suffered a devastating defeat to the Kansas City Chiefs in their last outing. Indianapolis enters Sunday's matchup favored by 5.5-points in the latest Broncos vs. Colts odds, while the Over-Under is set at 43. Before entering any Broncos vs. Colts picks, you'll want to see the NFL predictions from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on its top-rated NFL picks since its inception four years ago. It has nailed its recent top-rated NFL picks, entering Week 8 of the 2019 NFL schedule on a strong 24-17 run that dates back to last season. It's also on an incredible 86-60 roll on top-rated NFL picks that dates back to the 2017 season. And in Week 7, it nailed the Chiefs (-3) covering with plenty of room to spare against the Broncos and the Ravens (+3) staying within the spread against the Seahawks in a game Baltimore won outright by 14. The model also ranked in the Top 10 on NFLPickWatch for the third year in a row on straight-up NFL picks and beat more than 96 percent of CBS Sports office pool players. Anyone who has followed it is way up.

Now, it has simulated Colts vs. Broncos 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

The model has taken into account that Indianapolis has been extremely tough to beat at Lucas Oil Stadium. In fact, the Colts are 8-1 in their last nine games at home. In last week's home victory over the Texans, quarterback Jacoby Brissett threw for 326 yards and four touchdowns. Brissett ended up with a passer rating of 126.70. Not surprisingly, Brissett's sharp afternoon set his single-game touchdown high for the season. Wide receiver Zach Pascal also played extremely well against Houston, hauling in six receptions for 106 yards and two touchdowns. 

Denver, meanwhile, has to be hurting after a lopsided 30-6 loss at the hands of Kansas City. One thing holding the Broncos back was the mediocre play of quarterback Joe Flacco, who has failed to record a touchdown pass in each of his past two games. For the season, Flacco has thrown for 1,648 yards with six touchdowns and five interceptions. 

Two statistics to keep in mind before Sunday's kickoff: The Colts rank fourth in the league when it comes to passing touchdowns, with 14 on the season. However, the Broncos enter Sunday's matchup boasting the fourth fewest passing touchdowns allowed in the league at six. These opposing strengths should make for an exciting matchup.

So who wins Broncos vs. Colts? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine right now to see which side of the Broncos vs. Colts spread you need to jump on, all from the computer model that has crushed its NFL picks.