''We've got 82 games in the books,'' Toronto coach Sheldon Keefe said. ''Now we get to play for real.''
The Maple Leafs ensured they will face the two-time defending Stanley Cup champion Tampa Bay Lightning in the first round, while the Bruins are set to meet the Carolina Hurricanes.
''Back-to-back champs, one of the best teams in the league,'' Nylander said about the Lightning. ''It's going to be a tough series, but it'll be a good battle for us.''
Toronto finished 54-21-7 for 115 points, 10 more than the previous franchise record set in 2017-18.
Ilya Mikheyev, Nick Abruzzese, with his first NHL goal, and Pierre Engvall, into an empty net, also scored for Toronto. Erik Kallgren made 24 saves.
Trent Frederic and Jake DeBrusk scored for Boston (51-26-5). Jeremy Swayman stopped 22 shots.
Having already locked up the Atlantic Division's No. 2 seed, the Maple Leafs rested Auston Matthews, Mitch Marner and John Tavares up front, while No. 1 goaltender Jack Campbell served as the backup. The Bruins were minus Patrice Bergeron, David Pastrnak, Brad Marchand, Taylor Hall and Charlie McAvoy.
Boston, which was playing the second of a back-to-back, still had a chance of catching Tampa Bay for third in the division entering play, instead finished as the Eastern Conference's first wild-card seed.
''You want to play every game you can,'' Bruins center Charlie Coyle said. ''No matter what night it is, who you're playing, you want to be in the lineup and make an impact.''
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