The Boston Red Sox (9-7) host the Cleveland Guardians (10-5) in the 2024 Patriots' Day game on Monday. The Red Sox head into this battle tied for sixth in the majors in team home runs (20) and are 22nd in batting average (.233). On the other side, the Guardians are fifth in the league in team ERA (3.20). Kutter Crawford (0-0, 0.57 ERA) will start for Boston, while Xzavion Curry (0-0, 0.00 ERA) is on the hill for Cleveland.

The first pitch is set for 11:10 a.m. ET. The Red Sox are listed at -139 on the money line (risk $139 to win $100) in the latest Guardians vs. Red Sox odds via SportsLine consensus. The over/under for total runs scored is 9. Before making any Red Sox vs. Guardians picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It is coming off a profitable 93-74 season on top-rated MLB picks, and it excelled on top-rated run-line picks, going 18-6 (+766). Anybody following has seen big returns.

Now, the model has set its sights on Red Sox vs. Guardians and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Guardians vs. Red Sox:

  • Guardians vs. Red Sox money line: Boston -139, Cleveland +111
  • Guardians vs. Red Sox run line: Boston -1.5 (+144)
  • Guardians vs. Red Sox over/under: 9 runs
  • CLE: +318 on money line this season
  • BOS: +160 on money line this season as the favorite
  • Guardians vs. Red Sox picks: See picks at SportsLine

Why you should back the Guardians 

Second baseman Andres Gimenez consistently makes an impact for this squad. Gimenez has quick hands and hips to turn on pitches around the plate. Defensively he has a good glove with the speed to fly to the ball. He is hitting .310 with eight RBI and an OPS of .813. Gimenez rolls into this matchup on a nine-game hitting streak. In his last outing, the 25-year-old was 1-of-4 with a base hit.

First baseman Josh Naylor is a great offensive presence. Naylor has a strong lower frame that helps him spray the ball to any part of the field. He is hitting .347 with four home runs and 12 RBI. In his previous outing, Naylor went 2-of-4 with a solo homer and a base hit. He's notched 2-plus hits in three of his last five games. See which team to pick here.

Why you should back the Red Sox

Right fielder Tyler O'Neill brings outstanding power to the dish. O'Neill creates superb bat speed that allows him to drill the baseball around the diamond. He is first in the MLB in home runs (7), fifth in OPS (1.209) with eight RBI. O'Neill is also batting 304. In the April 9 win over the Baltimore Orioles, O'Neill was 1-of-4 with a solo homer.

First baseman Triston Casas (6-foot-5, 245 pounds) has a massive frame in the box and has the power to push the ball into the gaps. The 24-year-old has a .259 batting average with four home runs and eight RBI. In his last game, Casas was 1-of-4 with a two-run homer. See which team to pick here.

How to make Guardians vs. Red Sox picks

SportsLine's model is leaning Over on the total, projecting 9.5 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Red Sox vs. Guardians, and which side should you back? Visit SportsLine now to see which side you need to jump on, all from the model that went 18-6 on top-rated MLB run-line picks last season, and find out.