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Real Betis will be looking for a boost from the home crowd Wednesday when they host league leader Barcelona in a Spanish La Liga match in Seville, Spain. Real Betis (9-4-5) have beaten Barcelona (15-2-1) just once in their past eight meetings, but Los Verdiblancos have lost just once at home this season. The last meeting between the teams came three weeks ago in the Spanish Supercopa semifinals, and it ended in a 2-2 draw. Barcelona won 4-2 in a penalty shootout. Both teams are strong defensively and come in off 1-0 victories. Betis edged Getafe on the road last Saturday, while La Blaugrana won away at Girona the same day. Barcelona have a five-point lead over Real Madrid after their rivals drew 0-0 with Real Sociedad on Sunday.

Kickoff is set for 3 p.m. ET at Benito Villamarin Stadium. Caesars Sportsbook lists Barcelona as -135 favorites (risk $135 to win $100) in the latest Real Betis vs. Barcelona odds. Real Betis are +380 underdogs, a draw is listed at +265, and the over/under for total goals is 2.5. Before locking in any Barcelona vs. Real Betis picks, make sure you check out the Spanish La Liga predictions and best bets from soccer insider Jon Eimer

Eimer, widely known as "Buckets," is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, Eimer has covered the English Premier League, Serie A, the FA Cup and much more.

He is 22-7 (+17.03) on all soccer article predictions for SportsLine in 2023, bringing a profit of more than $1,700 for $100 bettors. He also is a stunning 64-28-1 (69%) on his Premier League picks for SportsLine since the start of 2022, for a profit of more than $3,000. Anyone who follows him is way up.

Now, Eimer has broken down the Real Betis vs. Barcelona matchup from all sides. You can head to SportsLine to see his picks. Here are the betting lines and trends for Barcelona vs. Real Betis:

  • Barcelona vs. Real Betis spread: Barcelona -0.5 (-150)
  • Barcelona vs. Real Betis over/under: 2.5 goals
  • Barcelona vs. Real Betis money line: Betis +380, Barcelona -135, Draw +265
  • BET: Real Betis have outscored their past eight league opponents 10-5
  • BAR: Barca have a 20-1 goal advantage in their past eight games in La Liga
  • Barcelona vs. Real Betis picks: See picks at SportsLine

Why you should back Barcelona

The difference for La Blaugrana this season has been their stellar defensive. They added Robert Lewandowski to the attack, and he has come as advertised, but the back line and Marc-Andre ter Stegen have been otherworldly. The goalkeeper has a league-best 90.2 save percentage to go with an astonishing 14 clean sheets in 18 La Liga matches. Barca have allowed six goals, three of those in a loss to Real Madrid in October. They have allowed just 39 shots on target, allowing just over two per game out of eight total attempts. The Barcelona attack has put a league-high 100 on frame.      

Barcelona's attack is nothing to sneeze at, as Lewandowski leads a team that has scored 37 goals, one shy of Real Madrid's league-best mark. The Polish striker leads La Liga with 13 goals and has scored 22 in 22 matches overall. Pedri has scored in three of his past four matches. 

Why you should back Real Betis

Los Verdiblancos also have an excellent back line, conceding 14 goals in their 18 league matches. They will fight tooth-and-nail for a victory that could put them right in the mix for a top-four spot, and they have been tough to crack at home. Betis have scored 12 goals and allowed five in eight matches at Benito Villamarin, going 5-2-1. Barca, meanwhile, suffered their only loss away from Camp Nou and conceded five of their six goals this season on the road. 

Real Betis should have confidence from the last meeting, when they equalized in both regulation and added time for the draw. The last matchup's result was not a fluke, as Betis had the edge in shots (15-12) and attempts on target (7-6). This despite holding the ball just 39% of the match. Borja Iglesias is tied for third in the league with nine goals, scoring on a penalty against Getafe to snap a seven-match drought. Nabil Fekir returned from injury to come off the bench Saturday, and he has a goal and two assists in 11 matches. He leads the league in shot-creating actions per 90 minutes at 6.15. 

How to make Real Betis vs. Barcelona picks

Eimer has broken down Wednesday's Real Betis vs. Barcelona match from every angle. He is taking the Over on the goal total and has two other best bets, and his full breakdown of the La Liga matchup. He's only sharing those picks at SportsLine.

So who wins Barcelona vs. Real Betis in Wednesday's La Liga match? And where does all the betting value lie? Visit SportsLine now to see the best bets for the Real Betis vs. Barcelona match, all from the soccer expert up more than $1,700 on his soccer picks in 2023, and find out.