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Paris Saint-Germain have confirmed that they will be without Kylian Mbappe for Wednesday's crunch Champions League Group H clash away at RB Leipzig on CBS All Access -- a rematch of August's semifinal in Lisbon.

The France international picked up a hamstring problem in the 3-0 Ligue 1 win away at Nantes over the weekend and the club have announced that he is not fit enough to make the trip as his status "will be reassessed in 48 hours."

"Kylian Mbappe's injury is a slight one," PSG manager Thomas Tuchel during Tuesday's prematch press conference. "However, it is a risky area. He should not play on it, which is a shame for us. We must find solutions without him.   

"We are missing some key guys, but we are going to try to play as more of a team. A bit more effort, a bit more mentality. We will identify a confident starting XI that is worthy of the Champions League."

PSG are already without Neymar until after the international break because of an adductor issue suffered last week in the 2-0 win away at Istanbul Basaksehir.

On top of Mbappe and Neymar, Marco Verratti remains absent with a quadricep injury and is not expected to feature again until after the November internationals.

PSG added that Mauro Icardi and Julian Draxler are working their way back to fitness, although Rennes this weekend in Ligue 1 will likely come too soon.

"We need 11 key guys, not just one or two," Tuchel added. "This is decisive, like a round of 16 clash. We know that situation well. It will be totally different to the Lisbon semi -- just look at the absentees."     

In better news for Tuchel, Angel Di Maria is available again after completing his domestic suspension and Leandro Paredes is back in the squad to boost midfield options.

"Of course it's not a disadvantage that Mbappe and Neymar won't play -- they are fantastic players -- but PSG have other very good players that many teams in Europe would like to have in their ranks," RB Leipzig manager Julian Nagelsmann said a press conference on Tuesday, whose team will be down Lukas Klostermann and Konrad Laimer due to knee injuries.

"It's definitely not the worst time to face them, but we also have several injured players."