The San Francisco Giants seek their fifth consecutive victory when they host the St. Louis Cardinals for the third contest of their four-game series on Wednesday (9:45 p.m. ET) at Oracle Park. After beginning the set with a 4-0 victory, San Francisco (10-13) trailed by two runs in the bottom of the ninth inning on Tuesday before Mike Yastrzemski delivered an RBI double and Blake Sabol belted a two-run homer on a 1-2 count with two outs for the walk-off win. On Wednesday, both teams are listed at -110 (risk $110 to win $100) in the latest MLB odds from Caesars Sportsbook, while over/under for total runs scored is 8.5.

The game is one of eight on the MLB schedule for Wednesday evening. Elsewhere in the majors, the Los Angeles Dodgers (-145) aim for their fourth consecutive victory when they visit the Pittsburgh Pirates and the Tampa Bay Rays (-120) look to improve to 15-1 at home when they host the Houston Astros. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it is on a 26-21 run dating back to the end of last season. Anybody who has followed it has seen profitable returns.

For Wednesday, the model has locked in three confident MLB best bets for games that begin at 6:35 p.m. ET or later. If you successfully parlay the picks, you'd be looking at a payout of well over 6-1. You can see the model's top MLB picks at SportsLine.

Top MLB picks today

After simulating every game on Wednesday 10,000 times, the model is picking the Dodgers (-140) to defeat the Pirates. Despite having three key hitters out of the lineup, Los Angeles rallied for an 8-7 win in Tuesday's series opener. The Dodgers trailed 7-2 after four innings but cut the deficit to two runs before Chris Taylor launched a three-run shot in the eighth to put them ahead.

The blast, which capped a 3-for-4 performance by Taylor, was Los Angeles' National League-leading 44th of the season. James Outman continued his torrid stretch at the plate, recording a pair of doubles to improve to 13-for-33 with four homers and nine RBI over his last eight games. The Dodgers will be looking for a strong effort from their bullpen as they expect about four innings from starter Tony Gonsolin, who will be making his season debut after suffering an ankle injury in spring training. The 28-year-old right-hander gave up one hit over five scoreless innings in a win against Pittsburgh last year and finished 2022 with a superb 16-1 record, 2.14 ERA and 0.87 WHIP. You can see who else to back here.

How to make MLB parlays for April 26

The model also locked in two other best bets for Wednesday, including a strong play for the Cubs vs. Padres showdown. You can see the model's best bets at SportsLine.

What MLB picks should you target for a payout of more than 6-1? And where is all the betting value for Cubs vs. Padres? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 26-21 run on top-rated money-line picks, and find out.