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Patrick Cantlay is expected to be among the top daily Fantasy golf picks this week for The American Express 2022. Cantlay secured a runner-up finish at this event last year, and he's coming off a top-five showing at the Sentry Tournament of Champions earlier this month. However, daily Fantasy golf players will have to decide if he can be trusted when setting their PGA DFS strategy for the 2022 American Express, which gets underway from La Quinta, Calif., on Thursday, Jan. 20. 

With a PGA DFS player pool featuring major champions like Patrick Reed, Phil Mickelson and Justin Rose, PGA DFS players will have to decide which golfers are worth investing in. Can any of those household names be relied on as PGA DFS picks this week? Or is it time to fade them in favor of players with a significantly lower price tag? Before you enter your PGA DFS lineups for The American Express 2022, you'll want to see the latest daily Fantasy golf picks, advice and player pool from SportsLine's Mike McClure.

McClure is a DFS pro with nearly $2 million in career winnings, and he's been red-hot on his PGA Tour picks this season. McClure is also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every tournament 10,000 times, taking factors like statistical trends, past results and current form into account. This allows him to find the best PGA DFS values and create optimal lineups that he shares only over at SportsLine. They're a must-see for any PGA DFS player.

Last week at the Sony Open, McClure included Russell Henley among his top PGA DFS picks. The result: Henley secured a second-place finish with a score of 23-under par, helping him return 151.6 points on FanDuel and 122.5 points on DraftKings. Anybody that included him in their lineups was well on the way to a profitable weekend.

In addition, McClure's model is up almost $10,000 on its best bets since the restart, nailing tournament after tournament. This same model has also nailed a whopping seven majors entering the weekend. Anyone who has followed it has seen massive returns.

Now, McClure has set his sights on the 2022 American Express and revealed his optimal PGA DFS advice, strategy and player pool. Head to SportsLine now to see his top daily Fantasy golf picks for The American Express 2022

Top 2022 The American Express PGA DFS picks

One of McClure's top PGA DFS picks for The American Express 2022 is Matthew Wolff at $9,300 on DraftKings and $10,900 on FanDuel. Wolff is a long ball hitter who's averaging 321 yards per drive this season, which ranks third on the PGA Tour.

Wolff's ability to drive the ball deep into the fairway will allow him to use his short irons to approach the green. That lethal combination has helped the 22-year-old hit over 72 percent of greens in regulation this season, which will come in handy this week at The American Express. Plus, Wolff has finished T-11 or better in each of his last three starts on the PGA Tour, making him an easy choice for your PGA DFS lineups.

McClure's optimal PGA DFS strategy also includes rostering Jon Rahm at $11,300 on DraftKings and $12,100 on FanDuel. The No. 1 ranked player in the world secured a runner-up finish at the Sentry Tournament of Champions earlier this month, shooting 66 or better in all four rounds. 

Rahm has now finished inside the top-10 in six of his last seven starts, which includes a victory at the U.S. Open. He has all the tools needed to return solid value for your PGA DFS lineups at The American Express 2022. In fact, Rahm enters this week's event ranked first in greens in regulation percentage (81.48), second in birdie average (6.17) and second in strokes gained: tee-to-green (1.760).

How to set 2022 The American Express PGA DFS lineups

McClure is also targeting an undervalued player who's primed to play extremely well this week, giving you a huge return on sites like DraftKings and FanDuel. Picks like these could be the difference between winning your PGA DFS contests or going home with nothing. You can only see who it is here.

So what are the top PGA DFS picks for The American Express 2022? And which undervalued golfer is a must-roster? Visit SportsLine now to see the complete player pool for FanDuel and DraftKings, all from the expert who's made nearly $2 million in daily Fantasy sports, and find out.