The Cleveland Browns (2-2) will be without starting quarterback Deshaun Watson when they host the San Francisco 49ers (5-0) on Sunday afternoon. Watson has been ruled out with a right shoulder injury, putting P.J. Walker in line to start. The Browns lost to Baltimore in a 28-3 final two weeks ago before having their bye last week. San Francisco has won four of its five games by double digits, including a 42-10 win against Dallas in primetime last Sunday.

Kickoff is set for 1 p.m. ET on Sunday at Cleveland Browns Stadium. San Francisco is favored by 9.5 points in the latest Browns vs. 49ers odds from the SportsLine consensus, while the over/under is 36 points. Before entering any 49ers vs. Browns picks, you'll want to see the NFL predictions from the advanced computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has set its sights on Browns vs. 49ers. You can head to SportsLine to see its picks. Here are several NFL betting odds and betting lines for 49ers vs. Browns:

  • Browns vs. 49ers spread: 49ers -9.5
  • Browns vs. 49ers over/under: 36 points
  • Browns vs. 49ers money line: 49ers: -515, Browns: +384
  • Browns vs. 49ers picks: See picks here
  • Browns vs. 49ers live stream: fubo (try for free)

Why the Browns can cover

San Francisco's offense is headed into its biggest challenge of the season, as Cleveland has the league's top-ranked defense. Browns defensive coordinator Jim Schwartz is 7-1 in his previous matchups against 49ers head coach Kyle Shanahan, and he has transformed Cleveland's defense in his first season on the job. The Browns lead the league in fewest yards allowed (196.8) and passing yards allowed (125.0). 

Myles Garrett headlines the charge with 5.5 sacks through his first four games, while Obo Okoronkwo has added 2.5. Cleveland had a week off following its ugly performance against Baltimore, putting the Browns in a good scheduling spot on Sunday against a San Francisco team that is coming off a primetime game. The Browns have won five of the last seven meetings between these teams. 

Why the 49ers can cover

San Francisco has been dominant so far this season, winning four of its five games by double digits. The 49ers crushed Dallas in primetime last week, easily covering the 3.5-point spread in a 42-10 final. Quarterback Brock Purdy completed 17 of 24 passes for 252 yards and four touchdowns, improving to 10-0 in his 10 career regular-season starts.

Purdy leads the NFL in passer rating (123.1), completing 72.1% of his passes for nine touchdowns and zero interceptions. Cleveland's defense leads the league in yards allowed per game, but it is coming off a 28-3 blowout loss to Baltimore its last time out. Walker had limited success in seven career starts across three seasons with Carolina, and he is now tasked with facing one of the league's best units in his first start for Cleveland. San Francisco has covered the spread in 13 of its last 16 games, while Cleveland is 0-6 against the spread in its last six games against NFC West opponents. See which team to pick here. 

How to make Browns vs. 49ers picks

The model has simulated 49ers vs. Browns 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick where one side has all of the value. You can only see the pick at SportsLine.

So who wins Browns vs. 49ers on Sunday, and which side of the spread has all of the value? Visit SportsLine right now to see which side of the 49ers vs. Browns spread you should be all over Sunday, all from the model on a 171-119 roll on its top-rated NFL picks, and find out.