A cross-conference affair in Week 4 involves the Dallas Cowboys (2-1) and the New England Patriots (1-2) squaring off on Sunday afternoon. The Cowboys look to bounce back in front of their home fans after a disappointing loss last week. Dallas suffered a 28-16 setback to the Arizona Cardinals after entering the game as 13-point favorites. On the other side, the Patriots beat the New York Jets for the 15th straight time with a 15-10 victory in Week 3. 

Kickoff from AT&T Stadium in Dallas is set for 4:25 p.m. ET. The Cowboys are six-point favorites in Patriots vs. Cowboys odds, while the over/under for total points is 43. Before making any Patriots vs. Cowboys picks, be sure to check out the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2023 NFL season on an incredible 167-117 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 21-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Patriots vs. Cowboys and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Patriots vs. Cowboys:

  • Cowboys vs. Patriots spread: Dallas -6
  • Cowboys vs. Patriots Over/Under: 43 points  
  • Cowboys vs. Patriots money line: Dallas -282, New England +231 
  • NE: Patriots are 1-2 against the spread in 2023
  • DAL: Cowboys are 2-1 against the spread in 2023
  • Cowboys vs. Patriots picks: See picks at SportsLine 
  • Cowboys vs. Patriots live stream: fubo (try for free)

Why Cowboys can cover

Through three weeks, the Cowboys rank fourth in the league in total defense (262) and second in pass defense (130.7). This unit is headlined by linebacker Micah Parsons. The two-time First Team All-Pro is relentlessly collapsing the pocket and putting pressure on opposing quarterbacks. Parsons has an elite step to get into the backfield quickly. He has 12 total tackles, five tackles for loss, and is tied for fourth in the NFL in sacks with four.

The 24-year-old has recorded a sack in all three games thus far. Defensive tackle Osa Odighizuwa is another impactful force up front for the Cowboys. Odighizuwa uses his strong hands and great awareness to make plays. The UCLA product has eight total tackles, four tackles for loss, and two sacks. See which team to pick here.

Why Patriots can cover

The Patriots have a way of forcing offenses to adapt to them. Linebacker Matthew Judon continues to be a consistent and effective rusher. Judon owns a great pass-rush plan and has good play recognition to stop the run. The four-time Pro Bowl selection has registered 11 total stops, five tackles for loss, with four sacks. In Week 3 versus the Jets, Judon had four total tackles and two sacks.

Safety Kyle Dugger is a very athletic and powerful defender in the secondary. Dugger explodes to the ball and has been a big-time tackler. The 2020 second-round pick is fourth on the team in total tackles (15) with two tackles for loss and two pass deflections. Linebacker Ja'Whaun Bentley excels at being a contributor at the second level. Bentley has a knack for being around the ball. The Purdue product leads the team in total stops with 21. He's logged five-plus stops in three straight matchups. See which team to pick here.

How to make Patriots vs. Cowboys picks

SportsLine's model is leaning Under the total, projecting the teams to combine for 42 points. The model also says one side of the spread is the better value. You can only get the model's pick at SportsLine

So who wins Patriots vs. Cowboys, and which side of the spread is the better value? Visit SportsLine now to see which side of the spread you need to jump on, all from the model on a 167-117 run on top-rated NFL picks, and find out.