There's only one matchup on the Week 3 NFL schedule that features two undefeated teams. The Tampa Bay Buccaneers and Philadelphia Eagles are both off to a 2-0 start and they'll square off on Monday Night Football. The Week 3 NFL odds from the SportsLine consensus list the Eagles as 5-point favorites in that one. The Eagles have struggled on the road against Tampa Bay, losing five of their last six road games against the Buccaneers.

Should your Week 3 NFL office pool picks include backing the Eagles on the road, and which other teams should you target as you make your NFL pool picks? Before you make your NFL predictions, you need to see the Week 3 NFL football pool picks from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2023 NFL season on an incredible 164-117 run on top-rated NFL picks that dates back to the 2017 season. It is also on an 18-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated the entire Week 3 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Head to SportsLine to see them now.

Top Week 3 NFL office pool predictions

One of the top Week 3 NFL predictions from the model: The Miami Dolphins (-7) comfortably beat the Denver Broncos at home. The Dolphins have been firing on all cylinders to start the season. Miami's offense is averaging 462.5 yards per game, which ranks first in the NFL. The Dolphins also lead the league in passing yards per game with 355.0. 

Quarterback Tua Tagovailoa has completed 65.3% of his passes for 715 yards and four touchdowns this season. His favorite target is wide receiver Tyreek Hill, who's hauled in 16 receptions for 255 yards and three scores in his first two games. Miami's dynamic duo will get a mouthwatering matchup on Sunday against a Broncos defense that allowed Commanders QB Sam Howell to throw for 299 yards and two touchdowns last week. According to the model, the Dolphins win in over 70% of simulations behind a strong performance from Miami's offense. See the rest of the model's Week 3 NFL pool picks here.

How to make Week 3 NFL office pool picks

The model also made the call on every other Week 3 NFL game and has strong picks for potentially close matchups like Saints vs. Packers, Patriots vs. Jets, and Steelers vs. Raiders. It's also calling for several favorites to struggle big-time. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 3 NFL game, and which favorites should you avoid? Visit SportsLine now to get optimal NFL office pool picks, all from a proven computer model that has returned over $7,000 since its inception, and find out.