Coming off a bye week, the Packers are the only team in the NFL with a perfect record against the spread. They'll put their streak on the line as one-point favorites against the Buccaneers in the latest Week 6 NFL odds from William Hill. That line opened with the Packers favored by 2.5, but we saw heavy movement throughout the week. In fact, the over-under also jumped from 52 to 55. It's one of eight games on the Week 6 NFL schedule with a spread of three points or fewer.
Panthers vs. Bears also has one of the tighter Week 6 NFL spreads, with Carolina favored by one. Both teams are 3-2 against the spread on the season and have three outright wins as underdogs, but this will be Carolina's first game as a favorite. All of the Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 6 NFL picks now.
The SportsLine Projection Model simulates every NFL game 10,000 times and is up over $7,500 for $100 players on its top-rated NFL picks since its inception five-plus years ago.
It's off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 roll on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.
Top NFL predictions for Week 6
One of the top Week 6 NFL predictions the model recommends: The Ravens (-9.5) cover the spread on the road against the Eagles. Philadelphia is 1-3-1 straight-up this season and just 1-4 against the spread. The Ravens, meanwhile, have a 4-1 straight-up record with a 3-1-1 mark against the spread.
Philly has been hit hard by injuries and could be missing multiple receivers. The Eagles could be without star offensive lineman Lane Johnson as well after he hurt his ankle against Pittsburgh last week. Baltimore hasn't been fazed playing on the road, as it has covered in six of its last seven away games. SportsLine's model has the Ravens covering the spread well over 60 percent of the time, with the over (46.5) clearing by half-a-point.
Another one of the top Week 6 NFL picks from the model: Indianapolis covers as an eight-point favorite over Cincinnati. While new Colts quarterback Philip Rivers has been up and down, Indianapolis' defense makes the team an AFC playoff contender. The Colts rank second in the NFL in scoring defense and first in total defense despite giving up season-highs in points (32) and yards (385) in a loss to the Browns last week.
Now, they'll take on a Bengals team that has one of the softest offensive lines in football. Cincinnati averages just 3.9 yards per carry and has allowed 22 sacks.
The model says the Colts cover well over 50 percent of the time. You can also book the over (46), which hits more than 60 percent of the time.
How to make Week 6 NFL picks
The model also has made the call on every other game on the Week 6 NFL schedule. It's also identified a Super Bowl contender that goes down hard. You can only get every pick for every game here.
What NFL picks can you make with confidence in Week 6? And which Super Bowl contender goes down hard? Check out the latest NFL odds from William Hill below and then visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,500 on its top-rated NFL picks.
NFL odds, matchups for Week 6
Denver Broncos at New England Patriots (-9.5, 44.5)
Chicago Bears at Carolina Panthers (-1, 44.5)
Detroit Lions at Jacksonville Jaguars (+3, 54.5)
Atlanta Falcons at Minnesota Vikings (-4, 54)
Houston Texans at Tennessee Titans (-3.5, 53.5)
Washington Football Team at New York Giants (-3, 43)
Cleveland Browns at Pittsburgh Steelers (-3.5, 51)
Baltimore Ravens at Philadelphia Eagles (+9.5, 46.5)
Cincinnati Bengals at Indianapolis Colts (-8, 46)
New York Jets at Miami Dolphins (-9.5, 47)
Green Bay Packers at Tampa Bay Buccaneers (+1, 55)
Los Angeles Rams at San Francisco 49ers (+3, 51.5)
Kansas City Chiefs at Buffalo Bills (+4.5, 47.5)
Arizona Cardinals at Dallas Cowboys (+1 55)