Buffalo has gone from the top of the AFC East to barely hanging on to a playoff spot following losses in four of its last six games. The Bills are currently the No. 7 seed in the AFC playoff picture, but they only have one game remaining against a team with a winning record. They will be trying to snap a two-game losing skid when they host Carolina on Sunday during the Week 15 NFL schedule. The Bills are 12-point favorites in the latest Week 15 NFL odds at Caesars Sportsbook.

Bettors have not shied away from backing Buffalo so far this week, moving the Bills from -9.5 to -12 in the NFL spreads. Should you put your money on them as well? All of the Week 15 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 15 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 15 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 15 NFL predictions

One of the model's strongest Week 15 NFL picks is that the Saints (+11.5) cover the spread against the Buccaneers. The Saints snapped a five-game losing streak with a 30-9 blowout win over the Jets last week. Running back Alvin Kamara returned from a four-game absence, rushing for 120 yards and a touchdown. He also caught four passes for 25 yards, providing a much-needed spark to a struggling offense.

Quarterback Taysom Hill had an efficient performance following a disastrous game against Dallas, completing 15-of-21 attempts for 175 yards. He also rushed 11 times for 73 yards and two touchdowns. Tampa Bay is coming off an overtime win over Buffalo, so this is a letdown spot for the Buccaneers.

SportsLine's model expects Hill to rush for more than 50 yards on Sunday Night Football, which will keep Tampa Bay's defense off balance. The Saints are covering the spread in almost 60 percent of simulations, while the over (46.5) is hitting more than 50 percent of the time. 

Another one of its Week 15 NFL predictions: The Steelers (-1) cover against the Titans at home. The Steelers have no margin for error following their loss to Minnesota last week. They were able to score 28 points in the final 17 minutes of that game, but it was not enough to erase a four-score deficit. Pittsburgh has been much better at home, winning four of its last five games at Heinz Field.

Tennessee does not have the rushing attack to exploit Pittsburgh's run defense due to Derrick Henry's injury. The Titans only had 102 rushing yards on 34 attempts against Jacksonville last week. SportsLine's model does not project Tennessee's running backs to combine for more than 110 yards on Sunday, which will not be enough to pick up a road win. Pittsburgh is covering the spread in well over 50 percent of simulations.

How to make Week 15 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 15 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,200 since its inception, and find out.

Week 15 NFL odds, spreads, lines

Sunday, Dec. 19

Panthers at Bills (-12, 44)

Jets at Dolphins (-9.5, 41)

Cowboys at Giants (+10.5, 44.5)

Titans at Steelers (-1, 43)

Texans at Jaguars (-5, 39.5)

Cardinals at Lions (+13, 47.5)

Falcons at 49ers (-9.5, 46.5)

Bengals at Broncos (-3, 44)

Packers at Ravens (+6.5, 43.5)

Saints at Buccaneers (-11.5, 45)

Monday, Dec. 20

Raiders at Browns (-1, 41)

Vikings at Bears (+6, 44)

Tuesday, Dec. 21

Washington Football Team at Eagles (-8, 43)

Seahawks at Rams (-6, 45.5)