There will be plenty of familiarity when the Green Bay Packers visit Levi's Stadium on Saturday to face the San Francisco 49ers in an NFL Divisional Playoffs matchup. Packers vs. 49ers is the most common playoff matchup since the AFL/NFL merger, with the teams facing off for a 10th time in Saturday's NFC Divisional Round. The 49ers have won four straight and have a 5-4 edge in postseason meetings. San Francisco head coach Kyle Shanahan and Packers counterpart Matt LaFleur also have worked together at three previous coaching stops. The 49ers (12-5) are the NFC's top seed and had a bye last week, while the Packers (10-8) upset the Cowboys 48-32 on the road in the Wild-Card Round last Sunday.

Saturday's kickoff in Santa Clara, Calif., is set for 8:15 p.m. ET. The latest Packers vs. 49ers odds list San Francisco as a 10-point favorite, and the over/under for total points scored is 50.5. Before making any 49ers vs. Packers picks, make sure you check out what SportsLine NFL expert R.J. White has to say, given his mastery of picks in games involving the Packers.

White, a fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and went 535-450-30 on his ATS picks from 2017-22, which returned more than $3,500 to $100 players. He also closed the 2022 NFL season on an incredible 107-80-6 run on his last 193 against-the-spread and total NFL picks, returning more than $1,800 for $100 bettors.

What's more, White is an incredible 66-27-2 on his last 95 picks involving the Packers for a profit of $3,457 for $100 bettors. Anyone who has followed him is way up.

Now, White has set his sights on Packers vs. Niners and just locked in his picks and NFL predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Niners vs. Packers:

  • Packers vs. 49ers spread: San Francisco -10
  • Packers vs. 49ers over/under: 50.5 points
  • Packers vs. 49ers money line: San Francisco -479, Green Bay +363
  • GB: Packers are 4-1 against the spread in their last five divisional playoff matchups
  • SF: 49ers are 7-2 ATS in nine playoffs games under Kyle Shanahan
  • Packers vs. 49ers picks: See picks at SportsLine
  • Packers vs. 49ers live stream: fubo (try for free)  

Why the 49ers can cover

San Francisco is 12-6 against the spread as a home favorite over the past two seasons and has proven all season it is one of the league's most well-rounded teams. The 49ers score 28.9 points per game and give up 17.5, with both marks ranking third in the NFL. They also are plus-10 in turnover margin, while the Packers are even. With two MVP candidates in the backfield and a bevy of talented pass-catchers, the San Francisco offense is a matchup nightmare for defenses.

NFL rushing champion Christian McCaffrey (1,459 yards) will face a Packers defense that allows 128 rushing yards per game (28th in NFL). If Green Bay sells out to contain McCaffrey, quarterback Brock Purdy (4,281 yards, 31 TDs) can make them pay. Purdy has two 1,000-yard receivers - Brandon Aiyuk (1,342) and tight end George Kittle (1,020). Versatile receiver Deebo Samuel (1,117 total yards) is also tough to stop, and McCaffrey also has 562 receiving yards. See which team to pick here

Why the Packers can cover

Green Bay proved last week that it won't be intimidated and quarterback Jordan Love has been on a tear. In his first full season as a starter, Love threw for 4,159 yards and 31 touchdowns in the regular season, then put up 272 and three TDs last Sunday. Aaron Jones also scored three times and rushed for 118 yards, his fourth straight game over 100. The Packers handed Dallas its first home loss all season, and the 48 points tied for second-most by a road team in playoff history.

Love has thrown 21 touchdowns passes and one interception over the past nine games, going 7-2. The Packers are 7-4 ATS as an underdog this season, winning the past four straight-up. Green Bay also has a strong young receiving corps, posting the most receiving yards and TDs by first- and second-year players in a season in NFL history. Second-year man Romeo Doubs had 151 receiving yards last week, and rookie tight end Luke Musgrave had 52 yards and a TD. See which team to pick here

How to make Packers vs. 49ers picks

White has analyzed this matchup and is leaning Over the point total, but he has discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

Who wins 49ers vs. Packers in the 2024 NFL playoffs, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the 49ers vs. Packers spread to back, all from the expert on a 66-27 roll on picks involving Green Bay.