The New Orleans Saints will hit the road on Friday as part of the 2022 NFL Week 2 preseason schedule. New Orleans lost its preseason opener to the Houston Texans last week and was 9-8 last season, falling short of the NFL playoff picture. The Packers were 13-4 in 2021, winning the NFC North, and also lost their preseason opener in San Francisco against the 49ers.

Kickoff is at 8 p.m. ET in Green Bay. Caesars Sportsbook lists the Packers as three-point home favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 39.5 in the latest Saints vs. Packers odds. Before you make any Packers vs. Saints picks and NFL predictions, you need to see what SportsLine NFL expert R.J. White has to say.

Over the past seven years White, a CBS Sports fantasy and gambling editor, has gone 329-250-21 (56.8 percent) in the world's most prestigious football handicapping competition, the Las Vegas SuperContest. He also is SportsLine's No. 1 NFL expert, going 445-378-24 on his against-the-spread NFL picks from 2017-21, returning $2,542 to $100 players. 

In addition, White has gone 50-17-1 on his last 68 against-the-spread picks involving the Packers, returning more than $3,000. Anyone who has followed him is way up.

Now, White has set his sights on Saints vs. Packers and just locked in his picks and NFL predictions. You can head to SportsLine now to see White's picks. Now, here are several NFL odds and betting lines for Saints vs. Packers:

  • Saints vs. Packers spread: Packers -3 
  • Saints vs. Packers over-under: 39.5 points 
  • Saints vs. Packers money line: Packers -150, Saints +130 
  • NO: Saints are 7-3 against the spread in the last 10 against Green Bay 
  • GB: Packers are 1-6 against the spread in last seven preseason games 
  • Saints vs. Packers picks: See picks here

Why the Saints can cover

The Saints have a battle going at the running back spot for insurance behind Alvin Kamara and Mark Ingram. Tony Jones Jr. is the incumbent, and the 24-year-old from Notre Dame rushed for 142 yards and made three starts last season. Devine Ozigbo is a three-year veteran from Nebraska with experience for the Jaguars and Saints. Dwayne Washington is the most veteran option with six years of experience and more than 600 career yards between Detroit and New Orleans. Finally, Abram Smith is a rookie from Baylor with flashing talent and intrigue.

All eyes will be on that backfield, and the Saints have a high-end backup quarterback in Andy Dalton to make it all work. The 11-year veteran is a three-time Pro Bowl selection with more than 35,000 career passing yards and logged six starts for the Chicago Bears last season. He also completed all five of his passes in the preseason opener.

Why the Packers can cover

Green Bay projects to have a stellar defense in 2022, and the Packers ranked in the top 10 of the NFL in multiple defensive metrics last season. The team held the 49ers to only 3.6 yards per carry in last week's preseason opener. On the offensive side, Romeo Doubs is a budding standout in training camp, as the fourth-round pick is showcasing his considerable talent in a wide receiving corps that has uncertainty without Davante Adams. Doubs produced more than 1,100 yards in his final college season at Nevada and contributed more than 3,300 yards and 26 touchdowns in his collegiate tenure.

The Packers have a high-upside backup quarterback in Jordan Love. The former first-round pick has preseason experience, including two starts in 2021, and threw for more than 400 yards in his only regular season start last season.

How to make Saints vs. Packers picks

White has analyzed this matchup and while we can tell you he's leaning under on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Saints vs. Packers? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see White's Saints vs. Packers picks, all from the expert who is an amazing 50-17 on Green Bay picks, and find out.