The New England Patriots will hope to continue their dominance in the all-time series when they meet the Indianapolis Colts on Sunday at Frankfurt Stadium in Germany. New England (2-7) has lost five of its last six games this season, but has had Indianapolis' number of late, winning nine of their last 10 meetings, including two in the postseason. The Colts (4-5) are looking to post back-to-back victories and get to .500 after registering a 27-13 victory at Carolina last week.

Kickoff is set for 9:30 a.m. ET. Indianapolis is a 2-point favorite in the latest Colts vs. Patriots odds, while the over/under for total points scored is 43. Before making any Patriots vs. Colts picks of your own, you need to see the NFL predictions and betting advice from SportsLine's Advanced Computer Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 10 of the 2023 NFL season on an incredible 174-123 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-15 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on Colts vs. Patriots and just revealed its picks and predictions. You can only see the model's picks at SportsLine. Here are several NFL odds and betting lines for Patriots vs. Colts:

  • Colts vs. Patriots spread: Indianapolis -2
  • Colts vs. Patriots over/under: 43 points
  • Colts vs. Patriots money line: Indianapolis -129, New England +108
  • IND: Over has hit in six of the Colts' nine games this season
  • NE: Patriots are 2-7 against the spread this year, but 3-0 all-time in international games
  • Colts vs. Patriots picks: See picks here

Why the Colts can cover

Indianapolis ranks seventh in the NFL in scoring, averaging 25.8 points per contest. In fact, the Colts are the only team in the league that has scored at least 20 points in every game this season. The club has rushed for 12 touchdowns, with Zack Moss leading the way with five, and thrown for 11 while adding three defensive scores, including two by cornerback Kenny Moore II on pick-sixes last week.

Gardner Minshew's ability to hold on to the football will be a key for Indianapolis to be successful. The 27-year-old quarterback has thrown just one interception and lost one fumble in his 10 career wins as a starter, but was picked off 17 times and lost 15 fumbles in his 19 losses. The Colts have gone 4-0 this season when Minshew does not commit a turnover and 0-3 when he does. See which team to pick here.

Why the Patriots can cover

With leading receiver Kendrick Bourne (knee) already out, New England is hoping Demario Douglas is able to overcome his ankle ailment and be on the field Sunday. The 22-year-old rookie was the top receiver in last week's 20-17 loss to Washington, gaining a season-high 55 yards on five catches. Douglas is tied with tight end Hunter Henry for second on the team with 277 receiving yards.

Henry had his third touchdown reception of 2023 in Week 9 after registering a total of two in 17 games last season. The TD pass was the fifth in five contests for quarterback Mac Jones, who went without one over his previous three outings. The 28-year-old Henry led the Patriots with 50 receiving yards in last year's 26-3 victory against the Colts. He hauled in a pair of scoring passes from Jones in the fourth quarter while finishing with a team-high 77 yards in New England's 27-17 setback at Indianapolis the previous season. See which team to pick here.

How to make Colts vs. Patriots picks

SportsLine's model is leaning Over the point total, predicting 44 total points. The model also says one side of the spread hits in well over 50% of simulations. You can see the model's NFL picks and analysis only at SportsLine

So who wins Patriots vs. Colts in Germany, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Patriots vs. Colts spread you should jump on, all from the advanced model that is up more than $7,000 on top-rated NFL picks, and find out.