The Philadelphia Eagles will look to stay atop the NFC East when they visit the Seattle Seahawks on Monday Night Football at Lumen Field. By virtue of the Cowboys' loss to the Bills on Sunday, Philadelphia (10-3) regained the top spot in the division over Dallas (10-4). An Eagles loss on Monday Night Football would give the division lead back to the Cowboys. Meanwhile Seattle (6-7) is looking to join four 7-7 teams that are chasing a wild card berth in the playoffs. Eagles quarterback Jalen Hurts (illness) and Seahawks quarterback Geno Smith (groin) are both active despite being listed as questionable.

Kickoff is at 8:15 p.m. ET in Seattle. The Eagles are four-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 45 in the latest Seahawks vs. Eagles odds. Before making any Eagles vs. Seahawks picks of your own, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2023 NFL season on an incredible 176-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 30-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Eagles vs. Seahawks and just locked in its picks and Monday Night Football predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Seahawks vs. Eagles: 

  • Seahawks vs. Eagles spread: Eagles -4
  • Seahawks vs. Eagles over/under: 45 points
  • Seahawks vs. Eagles money line: Eagles -161, Seahawks +136
  • PHI: Eagles are 4-2-1 against the spread in road games
  • SEA: Seahawks are 2-3-1 against the spread in home games
  • Seahawks vs. Eagles picks: See picks at SportsLine
  • Seahawks vs. Eagles live stream: fubo (try for free)

Why the Eagles can cover

Philadelphia's pass rush has a strong matchup against Seattle's pass protection. The Seahawks allowed four sacks last week against the 49ers. That bodes well for an Eagles defense that has 49 sacks on the season (fourth best in the league) and features Haason Reddick, who has 27 sacks over the past two seasons (third most in the NFL).

In addition, Philadelphia's offense gets a reprieve this week. After facing two straight top-five defenses in the 49ers and Cowboys, the Eagles square off against a Seahawks defense that ranks 25th in points per game allowed (24.5). Seattle also is 30th in third down conversions (45.8%) and 26th in red zone efficiency (65.0%). See which team to pick here.

Why the Seahawks can cover

Seattle is seemingly catching Philadelphia at the right time. The Eagles have scored only 32 total points in the last two games and have as many turnovers (19) this season as the team committed in the entire 2022 season. On the other side of the field, Philadelphia has given up 36.3 points per game over the last three games, yielding more than 450 total yards per game in that sample. The Eagles are also struggling on the whole defensively, giving up 25.7 points per game and 2.33 points per drive while allowing points on 40.0% of defensive possessions.

Philadelphia is in the bottom 10 in total yards allowed and yards allowed per play and is dead-last in third down efficiency allowed (48.1%). The Eagles are also struggling in the red zone, allowing opponents to convert more than 70% of opportunities into touchdowns. Seattle's offense also has strengths, including the team scoring points on more than 36% of offensive possessions. The Seahawks also have only 16 turnovers in 13 games, with only four lost fumbles in 2023. Seattle can also lean on the dynamic talent of DK Metcalf, with the Pro Bowl receiver averaging 16.9 yards per catch this season. That ranks No. 2 in the NFL, and Metcalf has more receiving touchdowns (five) than any NFL player since Week 11. See which team to pick here.

How to make Seahawks vs. Eagles picks on MNF

SportsLine's model is leaning over the point total, calling for 46 combined points. The model also says one side of the spread cashes in well over 50% of simulations. You can only see the model's MNF picks at SportsLine.

So who wins Eagles vs. Seahawks on Monday Night Football, and which side of the spread cashes well over 50% of the time? Visit SportsLine now to see which side of the Eagles vs. Seahawks spread you need to jump on, all from the model on a 176-129 roll on NFL picks, and find out.