Chiefs defensive coordinator Steve Spagnuolo can set the record for most Super Bowl wins by a coordinator when the Kansas City Chiefs square off against the San Francisco 49ers in Super Bowl 58 on Sunday at Allegiant Stadium in Las Vegas. The 64-year-old Spagnuolo has won three Super Bowl titles (two with the Chiefs and one with the Giants), which is tied with Josh McDaniels, Charlie Weis, Romeo Crennel and Richie Petitbon for the most ever by a coordinator. Spagnuolo already is the only coordinator to win Super Bowl titles with multiple teams. This year, his defense gave up just 289.8 yards per game in the regular season, which ranked second in the NFL.

The Super Bowl start time is set for 6:30 p.m. ET on CBS and Paramount+. San Francisco is a 2-point favorite in the latest 49ers vs. Chiefs odds, while the over/under for total points scored is 47.5. Before you make any Chiefs vs. 49ers picks or Super Bowl predictions of your own, you need to see what proven NFL expert Jason La Canfora has to say, considering he's entering the 2024 Super Bowl on a red-hot streak.

An NFL insider, La Canfora has covered the league for more than two decades for CBS Sports, The Washington Post and the NFL Network, among other outlets, and this season he became a regular contributor to SportsLine. He enters Super Bowl LVIII on a red-hot roll. La Canfora is 52-27 (+2202) on his last 79 NFL picks.

Now, La Canfora has locked in on 49ers vs. Chiefs from every angle and just locked in his picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and betting lines for Chiefs vs. 49ers: 

  • 49ers vs. Chiefs spread: San Francisco -2
  • 49ers vs. Chiefs over/under: 47.5 points
  • 49ers vs. Chiefs money line: San Francisco -128, Kansas City +108
  • SF: RB Christian McCaffrey led the league in rushing (1,459 yards)
  • KC: Chiefs ranked second in total defense (289.8 yards per game)
  • 49ers vs. Chiefs picks: See picks at SportsLine 
  • 49ers vs. Chiefs live stream: Paramount+ (try for free)

Why the 49ers can cover

San Francisco has arguably the best running back in the league in Christian McCaffrey. The rushing and pass-catching threat led the league in rushing (1,459 yards) during the regular season. He also added 564 yards and seven touchdowns catching the ball out of the backfield. His 2,023 yards from scrimmage during the season also led the NFL.

In addition, the 49ers have been lights-out in the second halves in the postseason. In the victories over the Packers and Lions, San Francisco has outscored its opponents by a combined 44-22. (By comparison the 49ers have been outscored in the first halves 30-14.) They also have won the second-half turnover battle 3-0. See which team to back here.

Why the Chiefs can cover

Kansas City's offense runs through one of the top quarterbacks of all-time in Patrick Mahomes, and his connection with Travis Kelce will almost certainly be high on the list of San Francisco's defensive priority list. However, the Chiefs also project well against San Francisco's rushing defense, as the 49ers have allowed the most rushing yards per game (159.0) of any team to reach the Super Bowl since 1966. The 49ers have allowed a 90-yard rusher in both playoff games and gave up 148 rushing yards in the first half of the NFC Championship Game, the most allowed in any first half since Kyle Shanahan took over as the team's head coach.

Opponents are averaging 5.6 yards per carry against the 49ers in the playoffs and San Francisco appears to be vulnerable to outside runs. The 49ers have allowed 231 yards and a blistering 8.3 yards per carry on designed runs outside the tackle box during their playoff run, and the Chiefs have averaged 5.0 yards per carry on these rush attempts during this postseason. Kansas City running back Isiah Pacheco projects to be heavily featured for the Chiefs and had 1,179 yards from scrimmage and nine touchdowns in 14 regular season games. Pacheco has also found the end zone in seven straight games, the longest active streak in the NFL, and has at least 75 yards from scrimmage in all six playoff games during his career. See which team to pick here.

How to make 49ers vs. Chiefs picks

La Canfora has analyzed Chiefs vs. 49ers and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

Who wins Super Bowl 58, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Chiefs vs. 49ers spread hits hard, all from the expert who is 52-27 on his last 79 NFL picks, and find out.