Madison Square Garden showcases a matchup between power-conference foes on Tuesday evening. The Iowa Hawkeyes will take on the No. 15 Duke Blue Devils as part of the 2022 Jimmy V Classic in Manhattan. Iowa is 6-1 this season, including victories over a pair of ACC teams in Georgia Tech and Clemson. Duke has victories over Ohio State and Xavier, among others, and Jon Scheyer's team is 8-2 in its first 10 games.

Caesars Sportsbook lists the Blue Devils as 2-point favorites for this 9:30 p.m. ET tip. The total number of points Vegas thinks will be scored, or the over/under, is 148 in the latest Iowa vs. Duke odds. Before making any Duke vs. Iowa picks, you need to see the college basketball predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,400 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Iowa vs. Duke and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college basketball odds and betting lines and trends for Duke vs. Iowa:

  • Duke vs. Iowa spread: Duke -2
  • Duke vs. Iowa over/under: 148 points 
  • Duke vs. Iowa money line: Duke -135, Iowa +115
  • IOWA: The Hawkeyes are 5-2 against the spread this season 
  • DUKE: The Blue Devils are 5-5 against the spread this season 
  • Duke vs. Iowa picks: See picks here
Featured Game | Duke Blue Devils vs. Iowa Hawkeyes

Why Iowa can cover

Iowa is keyed by its offense, though the Hawkeyes also have clear defensive strengths. Iowa is in the top 10 of the country in adjusted offensive efficiency and scoring (86.4 points per game), and Iowa leads the nation with a 12.9% turnover rate. The Hawkeyes are also firmly above-average in offensive rebound rate (36.5%), 2-point shooting (54.1%), 3-point shooting (34.4%) and free throw shooting (73.7%), with Iowa also assisting on more than 60% of field goals. 

On defense, Iowa is elite at preventing free throws, ranking in the top five nationally in free throw creation rate allowed. Opponents are also shooting only 45.8% inside the 3-point arc against the Hawkeyes, with Duke shooting only 30.5% from long range this season. The Blue Devils are also below-average in free throw rate, and Iowa has a 20.6% turnover creation rate with a 10.5% steal rate this season.

Why Duke can cover

Duke's offense is keyed by freshman big man Kyle Filipowski, who is averaging more than 15 points and nine rebounds in only 27.5 minutes per game. The Blue Devils are in the top 20 in adjusted offensive efficiency so far this season, and rank No. 2 in the nation in offensive rebound rate at 41.0%. Duke is making 77.3% of its free throw attempts, and the Blue Devils protect the ball well with a 17.5% turnover rate and a 7.4% live-ball turnover rate. 

Iowa is below-average on the defensive glass, opening up an opportunity for Duke's size and athleticism. On defense, Duke is strong across the board, including a top-25 national mark in free throw rate allowed. The Blue Devils are also holding opponents to 26.7% 3-point shooting and 46.9% 2-point shooting, while also excelling with a 20.3% turnover creation and 10.8% block rates this season.

How to make Iowa vs. Duke picks

SportsLine's model is leaning Over on the point total, with seven players projected to score at least eight points. The model also says one side of the spread hits in more than 60% of simulations. You can only see the model's pick at SportsLine.

So who wins Iowa vs. Duke? And which side of the spread hits in more than 60% of simulations? Visit SportsLine now to see which side of the Iowa vs. Duke spread you need to jump on Tuesday, all from the model that has crushed its college basketball picks, and find out.