Head coach Deion Sanders and the Colorado Buffaloes (4-6, 1-6 Pac-12) look to keep their bowl hopes alive when they travel to Pullman, Wash., for a Friday night Pac-12 matchup with the Washington State Cougars (4-6, 1-6). The Cougars are also fighting for bowl eligibility and will be looking to snap a six-game losing streak after losing to Cal 42-39 in their last outing. The Buffs lost their fourth straight on Nov. 11, losing to Arizona 34-31 on a walk-off field goal despite another strong effort from quarterback Shedeur Sanders. Washington State leads the all-time series 7-6. 

Kickoff is set for 10:30 p.m. ET at Gesa Field in Pullman The Cougars are 4-point favorites in the latest Washington State vs. Colorado odds from SportsLine consensus. The over/under is 59.5. Before making any Colorado vs. Washington State picks, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, including a 5-1 mark in the CU vs. USC game and a 3-1 record in last week's Colorado-Arizona matchup. Overall, he's on a 59-23-2 roll on his college football best bets for SportsLine this season so far. He went 8-1 on his CFB Week 11 picks, returning a profit of $690 for $100 bettors. Anyone who has followed his picks is way up.

Now, he has set his sights on Colorado vs. Washington State and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Washington State vs. Colorado:

  • Washington State vs. Colorado spread: Washington State -4
  • Washington State vs. Colorado over/under: 59.5 points
  • Washington State vs. Colorado money line: Colorado +157, Washington State -188
  • CU: The Buffs are 6-3-1 against the spread in 2023.
  • WSU: The Cougars are 4-5 against the spread in 2023.
  • Washington State vs. Colorado picks: See picks at SportsLine
  • Washington State vs. Colorado live stream: fubo (try for free)

Why Colorado can cover

The Buffs enter this matchup on a three-game covering streak. All three covers came against ranked teams, and were in large part due to improved play on the defensive side of the ball. Cornerback Travis Hunter is likely going to earn All-Conference and All-America honors, and safeties Shilo Sanders (55 tackles, 2 forced fumbles, one interception) and Trevor Woods (56 tackles, 2 interceptions, 1 forced fumble, 0.5 sacks) have both played at a high level.

Quarterback Shedeur Sanders has been one of the top quarterbacks in the country all season. The 6-foot-2 junior has completed 69.5% of his passes for 3,144 yards, 26 touchdowns, three interceptions and four rushing touchdowns. His top target has been former transfer Xavier Weaver, who has 65 catches for 867 yards and four touchdowns. See which team to pick at SportsLine

Why Washington State can cover

Washington State showed that it can play with anyone in the conference during its four-game winning streak to open the season. The Cougars will be facing a Colorado offense that has allowed its starting quarterback to be sacked 49 times (second most in the FBS), and they have a pair of explosive pass rushers that could greatly impact this game in Brennan Jackson (6.5 sacks) and Ron Stone Jr. (3 sacks).

Washington State quarterback Cameron Ward has also proven to be one of the top quarterbacks in college football. The 6-foot-2 junior enters Friday's contest with 3,127 passing yards, 20 touchdown passes, five interceptions, 136 rushing yards and six rushing TDs. His top targets in 2023 have been wide receivers Lincoln Victor (73 catches, 723 yards, 4 TDs) and Kyle Williams (53 catches, 711 yards, 4 TDs). See which team to back at SportsLine

How to make Washington State vs. Colorado picks

Kaylor has analyzed this matchup from every angle and he's going Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Colorado vs. Washington State, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Colorado vs. Washington State picks, all from the expert who has covered college football for over a decade and is 59-23-2 on his CFB best bets in 2023, and find out.