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When the Philadelphia Eagles and Tampa Bay Buccaneers kick off on Thursday night there is only one running back you should feel good about starting in that game, Leonard Fournette. He is the No. 15 running back in Fantasy so far this season and the Eagles are giving up more than 160 yards per game to running backs this season. Fournette is a top-15 back in all formats for me this week and the only running back ranked in my top-24 from this game.

But that doesn't mean Fournette is the only running back you'll be starting rest of season. 

While things have been sketchy for Miles Sanders so far this reason, there's reason for hope after he faces the vaunted Tampa Bay run defense. Sanders played a season-high 75% of the snaps in Week 1, has at least three catches in four of five games this season, and ranks first among running backs this season in broken tackles per rush attempt.

None of that will probably matter to you against Tampa Bay on Thursday, but after that game Sanders gets the Raiders, Lions, and Chargers in his next three games. None of them have good run defenses. 

I wouldn't mind trying to buy low on Sanders before his game on Thursday, just in case he does what Myles Gaskin did to them, but I'll for sure be targeting him heading into Week 7.

Let's get to the rest of the Week 6 RB Preview:

Week 6 RB Preview
RB Preview
Who's Out

The following players are not being projected to play Week 6 at this time. Here's what it means:

Who's Out
Projections powered by Sportsline
KC Kansas City • #25
Age: 25 • Experience: 5 yrs.
Darrel Williams is a low-end No. 2 running back in Week 6.
PHI Philadelphia • #26
Age: 27 • Experience: 7 yrs.
Devontae Booker is a low-end No. 2 running back in Week 6.
RB Preview
Numbers to know
  • 289 -- Nick Chubb leads the NFL with 289 yards after contact. 
  • 5 -- Cordarrelle Patterson has at least five catches in four straight games. He's a "buy" for me heading into his bye.
  • 12.4 -- D'Andre Swift has scored just 12.4 PPR points in the first quarter this year. He's scored 36.1 in the fourth.
  • 2 -- Damien Harris has two fumbles on the year. There's a low degree of certainty who will lead the Patriots backfield in Week 6.
  • 20 -- Devonta Freeman played a season-high 20 snaps in Week 5. He's worth a speculative add, because whoever gets carries against the Chargers is likely to pop.
  • 74% -- Zack Moss's 74% snap share in Week 5 was the highest of his career.
RB Preview
Matchups that matter
Matchups that Matter
Projections powered by Sportsline
CLE Cleveland • #27
Age: 28 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
vs ARI CLE -2.5 O/U 50.5
OPP VS RB
7th
PROJ PTS
12.7
RB RNK
16th
YTD Stats
RUYDS
295
REC
17
REYDS
149
TD
5
FPTS/G
18.7
NE New England • #21
Age: 26 • Experience: 5 yrs.
Weekly Breakdown
MATCHUP
vs KC KC -6.5 O/U 55.5
OPP VS RB
23rd
PROJ PTS
15
RB RNK
19th
YTD Stats
RUYDS
313
REC
10
REYDS
119
TD
4
FPTS/G
15
CAR Carolina • #6
Age: 27 • Experience: 6 yrs.
Weekly Breakdown
MATCHUP
vs TB TB -7 O/U 51.5
OPP VS RB
14th
PROJ PTS
10.4
RB RNK
28th
YTD Stats
RUYDS
214
REC
16
REYDS
111
TD
0
FPTS/G
10.1
ARI Arizona • #6
Age: 29 • Experience: 8 yrs.
Weekly Breakdown
MATCHUP
@ CLE CLE -2.5 O/U 50.5
OPP VS RB
6th
PROJ PTS
8.3
RB RNK
34th
YTD Stats
RUYDS
201
REC
4
REYDS
34
TD
5
FPTS/G
11.5
RB Preview
Waiver Wire Targets
Week 6 Adds
LV Las Vegas • #34
Age: 34 • Experience: 12 yrs.
Weekly Breakdown
MATCHUP
vs DAL DAL -3.5 O/U 51.5
OPP VS RB
8th
RB RNK
35th
ROSTERED
15%
YTD Stats
RUYDS
29
REC
13
REYDS
80
TD
0
FPTS/G
4.8
The waiver wire is bare now that Darrel Williams and Devontae Booker have been added just about everywhere. But Bolden should be a solid option in full PPR in a game script where the Patriots figure to be chasing the score against the Cowboys. Bolden has 14 targets over his past three games and could get a few red zone carries after Damien Harris' Week 5 fumble.
Stash
CHI Chicago • #24
Age: 26 • Experience: 4 yrs.
Weekly Breakdown
MATCHUP
vs GB GB -4.5 O/U 44.5
OPP VS RB
17th
RB RNK
39th
ROSTERED
42%
YTD Stats
RUYDS
82
REC
0
REYDS
0
TD
0
FPTS/G
1.6
Herbert was the fourth-quarter hammer for the Bears in Week 5 and actually had more carries than Damien Williams. He probably needs an injury to Williams to be a Fantasy starter, but Williams has never held up to a 15-touch workload for very long.
NE New England • #38
Age: 26 • Experience: 4 yrs.
Weekly Breakdown
MATCHUP
vs DAL DAL -4 O/U 49.5
OPP VS RB
8th
RB RNK
NR
ROSTERED
21%
YTD Stats
RUYDS
25
REC
1
REYDS
9
TD
0
FPTS/G
1.2
You can't start Stevenson this week, but he could be the Patriots' lead running back as soon as Week 6.
MIA Miami • #23
Age: 28 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
vs IND
OPP VS RB
6th
RB RNK
NR
ROSTERED
18%
Hopefully we get an update on Wilson's injury status after the 49ers' Week 6 bye.
RB Preview
DFS Plays
Top Play
Projections powered by Sportsline
NO New Orleans • #24
Age: 29 • Experience: 6 yrs.
Weekly Breakdown
MATCHUP
@ WAS KC -6.5 O/U 55.5
OPP VS RB
19th
PROJ PTS
11.8
RB RNK
19th
YTD Stats
RUYDS
99
REC
7
REYDS
45
TD
2
FPTS/G
6.7
The pricing this week doesn't reflect Clyde Edwards-Helaire's injury, which should make Williams pretty chalky. In cash games, I'll play him anyway, whether I do in tournaments will likely depend on who comes back from injury this week. I expect 15-plus touches in a positive game script against a Washington defense that has been pretty terrible.
Contrarian Play
Projections powered by Sportsline
NYG N.Y. Giants • #28
Age: 32 • Experience: 6 yrs.
Weekly Breakdown
MATCHUP
vs LAR LAR -10.5 O/U 47.5
OPP VS RB
16th
PROJ PTS
9.5
RB RNK
23rd
YTD Stats
RUYDS
64
REC
6
REYDS
30
TD
2
FPTS/G
6.9
Devontae Booker is the (more expensive) alternate to Williams this week. He should see a similar workload, but the matchup and game script are much worse. And as good as the Rams defense is, four running backs have scored at least 17 PPR Fantasy points against it.
RB Preview
Heath's Projections

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 6 rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.