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Celtics forward Jaylen Brown was off to the best start of his career but will have to sit on the sideline for the next few weeks with a hamstring strain. Brown was leading Boston in scoring so others will have to fill his void, starting on Wednesday vs. the Raptors. Jayson Tatum has already shown he can go off for 50 in any given night, but others like Dennis Schroder, Marcus Smart and Robert Williams will also have to step up. That means the Celtics have several role players who are suddenly much more appealing for NBA DFS lineups thanks to the opportunities in front of them.

Williams leads the league with a 72.2 field-goal percentage, but will he be able to maintain that efficiency with more volume? And can either Smart or Schroder emerge in the backcourt and produce as one of the top NBA DFS picks? Before setting your NBA DFS strategy for Wednesday, be sure to check out the NBA DFS advice, player rankings, stacks and top daily Fantasy basketball picks from SportsLine's Mike McClure

McClure is a DFS professional with nearly $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account. 

This allows him to find the best NBA DFS values and create optimal lineups that he shares only over at SportsLine. They're a must-see for any NBA DFS player.

On Tuesday, McClure listed 76ers center Andre Drummond as a must-play on FanDuel and DraftKings. The result: Drummond went off with 17 points, 20 rebounds, three assists and two blocks to return 52.5 points on DraftKings and 51.5 points on FanDuel. Anybody that included him in their lineups was well on the way to a profitable day.

Now, McClure has turned his attention to the Wednesday, November 10 NBA DFS slate and locked in his top daily Fantasy basketball picks. You can only see them by heading to SportsLine.

Top NBA DFS picks for Wednesday, November 10

One of McClure's top NBA DFS picks for Wednesday is Pistons guard Cade Cunningham at $4,800 on FanDuel and $5,200 on DraftKings. The rookie had a rough start to his pro career with just eight total points over his first two games. But he's since showed why he was the No. 1 overall pick as Cunningham has averaged 17.5 points, 7.0 rebounds and 3.0 assists over his last two games.

On Wednesday Cunningham will face off against the Rockets and No. 2 overall pick Jalen Green. Many felt that Green should have went first overall, so expect Cunningham to be highly motivated to prove his merit as the top overall draft pick. Houston ranks 25th in points allowed per game so don't be surprised if Cunningham sets a new career-high in points in his young career.

Another key in McClure's optimal NBA DFS strategy includes rostering Nuggets forward JaMychal Green ($3,800 on FanDuel, $3,200 on DraftKings). Green is averaging 7.5 points and 4.3 rebounds in 12.5 minutes per game this month but is in line for much more playing time on Wednesday.

With Nikola Jokic suspended, and with both Jamal Murray and Michael Porter Jr. injured, Denver will be without its top three scorers. Thus, someone like Green will assume a much bigger role and he's proven he can produce when called upon. He had nine games with 15 or more points last season and gets a great matchup on Wednesday. Denver takes on Indiana which ranks 23rd in points allowed per game and is giving up 113.7 points per game on the road.

How to set NBA DFS lineups for Wednesday, November 10

McClure is also targeting a player who could go off for massive numbers on Wednesday because of a dream matchup. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here.

So who is DFS pro Mike McClure putting in his optimal NBA DFS lineups for Wednesday ? Visit SportsLine now to see optimal NBA DFS picks, rankings, advice, and stacks, all from a professional DFS player who has almost $2 million in career winnings, and find out.