The Arizona Cardinals will look to continue their recent dominance over the San Francisco 49ers when the NFC West rivals meet on Saturday. The Cardinals (8-6) have won nine of the last 11 meetings and are looking to earn their fifth season sweep of the 49ers (5-9) in the last six years. In the 19 years the teams have been division rivals, the Cardinals have won the season series nine times, the 49ers have won it six times, and they have split three times. Arizona holds a 14-13 record at home against San Francisco, including an 8-6 mark at State Farm Stadium.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 4:30 p.m. ET. The Cardinals are six-point favorites in the latest 49ers vs. Cardinals odds from William Hill Sportsbook, while the over-under for total points scored is 48.5. Before making any Cardinals vs. 49ers picks, check out the latest NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning more than $800. The model also enters Week 16 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up. 

Now, the model has set its sights on 49ers vs. Cardinals. You can visit SportsLine now to see the picks. Here are the NFL betting odds from William Hill and the latest trends for Cardinals vs. 49ers:

  • 49ers vs. Cardinals spread: Cardinals -6
  • 49ers vs. Cardinals over-under: 48.5 points
  • 49ers vs. Cardinals money line: 49ers +230, Cardinals -270
  • SF: 49ers are 1-6 against the spread in their last seven games
  • AZ: The Under has hit in eight Cardinals games this season

Why the Cardinals can cover

Arizona's offense is led by quarterback Kyler Murray, who has three or more touchdown passes in four of his last five home games. He has seven TDs, including five passing, against one interception for a 99.2 rating in three starts against San Francisco. He is looking for his third game in a row against the 49ers with a rushing score.

Wide receiver DeAndre Hopkins is Murray's favorite target. Last week against the Philadelphia Eagles, he had nine receptions for 169 yards and one touchdown. He is looking for his third game in a row with 125 or more yards and seventh in a row with five or more receptions.

He had 14 catches for 151 yards in the Week 1 meeting with the 49ers. Hopkins leads the NFL in receiving yards (1,324) and ranks second in receptions (103).

Why the 49ers can cover

San Francisco is still a formidable opponent despite the roster being decimated by injuries. Tight end George Kittle has been designated to return off of injured reserve, although running back Raheem Mostert and quarterback Nick Mullens will miss the rest of the season. Expected to start at quarterback is C.J. Beathard, who passed for 190 yards and a touchdown for an 83.9 rating in his last start at Arizona in October 2018. He has rushed for a TD in two of his three career starts against the Cardinals.

Running back Jeff Wilson has been a reliable backup for Mostert and rushed for 60 yards and a touchdown against the Cowboys last week. He has five rushing touchdowns in his past four road games and is looking for his third game in a row with a rushing score. For the year, he has carried the ball 84 times for 341 yards with 21 first-down conversions.

How to make 49ers vs. Cardinals picks

SportsLine's model is leaning under on the total, with the model suggesting neither team will have a rusher eclipse 55 yards. It also says one side of the spread hits in well over 50 percent of simulations. You can only get that pick at SportsLine.

So who wins Cardinals vs. 49ers on Saturday? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to see which side of the Cardinals vs. 49ers spread to jump on, all from the advanced model that is up almost $7,900 on its top-rated NFL picks, and find out.