NFL odds, lines, spreads, picks, predictions for Week 10, 2020: Proven model loving Buccaneers, Saints

SportsLine's computer model simulated every Week 10 NFL game 10,000 times with surprising results

By CBS Sports Staff

Nov 15, 2020 at 10:20 am ET • 4 min read

The Pittsburgh Steelers escaped a serious threat to their undefeated record last week, escaping Dallas with a 24-19 victory to improve to 8-0 for the first time in the franchise's storied history. Pittsburgh can run it to 9-0 this week when they welcome talented rookie quarterback Joe Burrow and the Cincinnati Bengals. The Bengals are 10-point underdogs according to the latest NFL odds from William Hill Sportsbook, one of the largest NFL spreads of the week and one of just two to reach double-digits.

Can Pittsburgh stay unbeaten and improve its hold on the AFC North, or can the Bengals spring the upset? And which games in Week 10 hold the most favorable matchups for your NFL bets? All of the Week 10 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now.

The SportsLine Projection Model simulates every NFL game 10,000 times and is up over $7,600 for $100 players on its top-rated NFL picks since its inception five-plus years ago.

It's off to a strong 16-9 roll on top-rated NFL picks this season. The model enters Week 10 on an incredible 112-73 roll on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, it has examined the latest Week 10 NFL odds and NFL betting lines from William Hill, simulated every snap, and its predictions are in. Head to SportsLine now to see them all.

Top NFL predictions for Week 10

One of the top Week 10 NFL predictions the model recommends: The visiting Tampa Bay Buccaneers (-6) cover as favorites against the Carolina Panthers. The Buccaneers are 9-2-1 against the spread in their last 12 games following a double-digit loss at home, while quarterback Tom Brady is still shining for the Buccaneers, throwing for 2,398 yards and 20 touchdowns against seven interceptions.

On the other sideline, the Panthers welcomed back superstar running back Christian McCaffrey last week, who romped to 151 yards of total offense and two touchdowns in a last-second, 33-31 loss to the Chiefs. McCaffrey, who had missed several games with a high ankle sprain, injured his shoulder against the Chiefs and is out Sunday.

SportsLine's model projects that Brady outplays Panthers quarterback Teddy Bridgewater and that the Panthers struggle to reach 100 rushing yards without McCaffrey. The model also says Tampa Bay covers in well over 50 percent of simulations. The over (51) has plenty of value because it hits almost 60 percent of the time.

Another one of the top Week 10 NFL predictions from the model: The Saints (-10) cover against the 49ers. After picking up four consecutive wins by one score, New Orleans left no doubt against Tom Brady and the Buccaneers last Sunday night. Drew Brees threw four touchdown passes as the Saints blasted their division foe by five touchdowns to take a half-game lead in the NFC South.

Now, the Saints will look to keep it rolling against a Niners squad that limps into town with a lengthy injury list. San Francisco is 2-4 overall and against the spread in its last six games and will start backup quarterback Nick Mullens against a New Orleans defense that just picked off Brady three times.

SportsLine's model gives Mullens a higher probability of throwing an interception than a touchdown, while Brees throws for over 250 yards and two scores as the Saints cover in well over 50 percent of simulations. The over (49) also has value since the teams combine to score 54 total points.

How to make Week 10 NFL picks

The model has also made the call on every other game on the Week 10 NFL schedule, and has identified a Super Bowl contender that goes down hard. You can only get every pick for every game here.

What NFL picks can you make with confidence in Week 10? And which Super Bowl contender goes down hard? Check out the latest NFL odds from William Hill below and then visit SportsLine to see which NFL teams are covering in more than 50 percent of simulations, all from the model that is up over $7,600 on its top-rated NFL picks.