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The Los Angeles Rams and San Francisco 49ers will put a bow on Week 10 in the NFL when these two NFC West rivals go toe to toe at Levi's Stadium tonight during "Monday Night Football." L.A. captured the attention of the league this week after it was able to sign wide receiver Odell Beckham Jr. following his release from the Browns. His addition has proven to be more of a necessity than the luxury it was initially billed as after fellow Rams receiver Robert Woods suffered a season-ending ACL tear during Friday's practice. That injury now thrusts Beckham into a bigger role within the offense as he's set to make his Rams debut. Meanwhile, the 49ers are looking to rebound following a loss to a hobbled Cardinals team in Week 9. 

Below, we'll specifically be looking at the different betting angles that this prime-time matchup has in store for us. We'll be taking a look at how the lines have moved throughout the week leading into Monday night and, of course, give you our picks for this game along with a handful of our favorite player props. 

All NFL odds via Caesars Sportsbook.

How to watch

Date: Monday, Nov. 15 | Time: 8:15 p.m. ET
Location: Levi's Stadium (Santa Clara, California)
ESPN | Stream: fuboTV (try for free)
Follow: CBS Sports App
Odds: Rams -3.5, O/U 50.5

Line movement

Latest Odds: San Francisco 49ers +3.5

The early spread for this game prior to Week 9 had the Rams as a field goal favorite. However, once the dust settled on last week's slate, the spread jumped up to Rams -4.5. It didn't hang at the number long coming out of Sunday, falling to Rams -4 and then hitting Rams -3.5 by Wednesday. It's largely stood firm at that number and remains Rams -3.5 on the eve of this head-to-head. 

The pick: Rams -4. Los Angeles will be looking to rebound following a surprisingly flat showing against the Tennessee Titans in Week 9, which I expect they will. Sean McVay's team is 12-3-1 ATS in their last 16 games following a loss. Meanwhile, the 49ers were torched at home last week by Colt McCoy, who completed nearly 85% of his passes. That's way more troublesome as this Rams offense is much more potent than the hobbled Cardinals unit they faced last week, even if L.A. is without Woods for the rest of the season. 

Key trend: 49ers are 0-4 ATS in their last four home games. 

Over/Under total

The total for this game has climbed considerably since the early look opened at 46.5. It shot all the way to 48 just before Week 9 kicked off and continued to balloon coming out of Sunday. By last Monday, the total stood at 49.5 and is now 50.5 coming into this prime-time matchup. 

The pick: Under 50.5. One way Kyle Shanahan could elect to limit the Rams' offense is by simply keeping the unit on the sideline by running the football. Hammering the ground game is already his preference and both of these teams average about 25 rushing attempts per game. Meanwhile, it's not out of the realm of possibility that L.A. struggles to find its footing as it works its way past losing Woods. For what it's worth, the Under is 6-2 in their last eight meetings in San Francisco. 

Key trend: Under is 3-1-1 in Rams last five games overall. 

Matthew Stafford props

Matthew Stafford
LAR • QB • 9
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  • Passing touchdowns: 2.5 (Over +165, Under -200)
  • Passing yards: 280.5 (Over -115, Under -115)
  • Total interceptions: 0.5 (Over +110, Under -140)
  • Completions: 24.5 (Over -115, Under -115) 
  • Passing attempts: 36.5 (over -110, Under -120)
  • Longest passing completion: 37.5 (Over -115, Under -115)
  • Rushing yards: 2.5 (Over -120, Under -110)

I'll lean Over on Stafford's passing yards prop of 280.5. He's gone over this total in six of his nine games, including three straight coming into Monday. This number could be a bit lower than normal with Woods out for the year, but San Francisco ranks 25th in the NFL against the pass in DVOA and is allowing 7.2 yards per attempt. Opposing quarterbacks are also completing 68.5% of their passes against this secondary.  

Jimmy Garoppolo props

Jimmy Garoppolo
SF • QB • 10
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  • Passing touchdowns: 1.5 (Over +110, Under -140)
  • Passing yards: 248.5 (Over +105, Under -135)
  • Total interceptions: 0.5 (Over -125, Unver -105)
  • Completions: 21.5 (Over -130, Under +100)
  • Passing attempts: 32.5 (Over -130, Under +100)
  • Longest passing completion: 36.5 (Over -115, Under -115)
  • Rushing yards: 3.5 (Over -115, Under -115)

Opposing quarterbacks are averaging nearly 39 pass attempts per game against Rams this season. If that trend holds, the Over would hit in Garoppolo's attempts prop for Monday night. The Rams are also allowing around 248 passing yards per game this season, which sits right on the line of Garoppolo's prop for this game. Over the last two weeks, Garoppolo is averaging 324 yards passing. 

Player props to consider

George Kittle total receiving yards: Over 56.5 (-110). Kittle looked like his old self last week, logging 101 receiving yards in his first game action since Week 4. While the Rams have a stout defense, Kittle has found success against this group in the past, averaging 92.3 yards per game in his seven career matchups with Los Angeles. 

Tyler Higbee total receptions: Over 4.5 (+115). Woods' targets will need to go somewhere and Higbee is tied with Van Jefferson for the third-most targets (46) on the team coming into Week 10. He's also fresh off a five-catch performance against the Titans in Week 9. Getting this at plus money does feel like solid value.