No. 18 Colorado will try to avoid getting caught looking ahead to its showdown with No. 13 Oregon when it hosts Colorado State on Saturday night. The Buffaloes made a statement in their season-opening upset win over then-No. 17 TCU before blowing out Nebraska last week. Colorado State is hoping to bounce back from a 50-24 loss to Washington State. This is the first meeting between these rivals since 2019, when Colorado beat Colorado State in a 52-31 final.

Kickoff is set for 10 p.m. ET at Folsom Field in Boulder. The latest Colorado vs. Colorado State odds via the SportsLine consensus list the Buffaloes as 23.5-point favorites, with the over/under at 63.5, which is up 4.5 points from the opener. Before entering any Colorado State vs. Colorado picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Colorado vs. Colorado State. You can head to SportsLine to see its picks. Here are several college football odds for Colorado State vs. Colorado:

  • Colorado vs. Colorado State spread: Colorado -23.5
  • Colorado vs. Colorado State over/under: 63.5 points
  • Colorado vs. Colorado State money line: Colorado: -2449, Colorado State: +1125
  • Colorado vs. Colorado State picks: See picks at SportsLine
  • Colorado vs. Colorado State live stream: fubo (try for free)

What you need to know about Colorado

Colorado has already doubled its win total from last season, with head coach Deion Sanders being the focal point of college football through the first two weeks of the season. Quarterback Shedeur Sanders is an early Heisman Trophy contender, racking up 903 passing yards, six touchdowns and zero interceptions. Wide receivers Jimmy Horn Jr., Travis Hunter and Xavier Weaver have each gone over the 180-yard mark, while running back Dylan Edwards has scored four total touchdowns.

Colorado State's defense did not show much promise in its opener, allowing 50 points to Washington State in a blowout loss. The Rams are having to start a freshman quarterback under center, as starter Clay Millen suffered an injury against Washington State. They have only picked up one win in their last nine road games, and they are 3-16 in their last 19 games overall. See which team to pick here.  

What you need to know about Colorado State

Meanwhile, Colorado State couldn't capitalize on its home-field advantage in its season opener. The Rams ended up on the wrong side of a painful 50-24 loss to Washington State's in Week 1. Despite the defeat, CSU had strong showings from receiver Justus Ross-Simmons, who scored a touchdown off of 123 receiving yards, and quarterback Brayden Fowler-Nicolosi, who threw for 210 yards and two touchdowns. Ross-Simmons made the highlight reel thanks to a 75-yard TD reception, while TE Dallin Holker also helped with a receiving touchdown.

The strength of the Rams is their defense, which got discernibly better as the season went on in 2022. After allowing 41 points per game through their first four games, the Rams gave up just 19.8 PPG over their last eight games. Defensive end Mohamed Kamara finished in the top four in the Mountain West in both sacks (8.5) and tackles for loss (16) last season, and he tallied one of each in the season opener. See which team to pick here.

How to make Colorado vs. Colorado State picks

The model has simulated Colorado vs. Colorado State 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread has all of the value. You can only see the pick at SportsLine.

So who wins Colorado State vs. Colorado, and which side of the spread has all of the value? Visit SportsLine now to see which side of the Colorado vs. Colorado State spread to jump on, all from the advanced computer model that's up more than $2,500 on its top-rated college football spread picks since its inception, and find out.