The Memphis Tigers aim to keep things rolling on Friday evening. Memphis is 4-1 to begin the 2022 season, including a pair of AAC victories. In the team's sixth game, Memphis will host the Houston Cougars at Liberty Bowl Memorial Stadium. Houston is 2-3 overall and 0-1 in AAC play, though the Cougars won the 2021 matchup between the two programs by a 31-13 margin at home.

Kickoff is set for 7:30 p.m. ET. The Tigers are 2.5-point favorites in the latest Memphis vs. Houston odds from Caesars Sportsbook. The over/under for total points is set at 57.5. Before making any Houston vs. Memphis picks, you need to see the college football predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Houston vs. Memphis and just locked in its picks and CFB predictions. You can head to SportsLine to see its picks. Now, here are several college football odds and betting lines for Memphis vs. Houston:

  • Houston vs. Memphis spread: Memphis -2.5
  • Houston vs. Memphis over/under: 57.5 points 
  • Houston vs. Memphis money line: Memphis -130, Houston +110
  • HOU: The Cougars are 1-4 against the spread in 2022 
  • MEM: The Tigers are 2-3 against the spread this season 
  • Houston vs. Memphis picks: See picks here
Featured Game | Memphis Tigers vs. Houston Cougars

Why Houston can cover

Led by Clayton Tune, the Houston offense is dangerous. The Cougars are averaging almost 31 points per game with three times as many touchdown passes as interceptions in 2022. Houston is moving the chains effectively, converting 50% of third down chances, and Tune has tremendous experience. The veteran signal-caller has more than 9,000 career passing yards with 1,201 yards and nine touchdowns in 2022. Tune is also capable on the ground with 193 rushing yards and two touchdowns, and he can connect with an elite pass-catching option in Nathaniel Dell

Dell ranks in the top five of the AAC with 33 catches and 453 yards this season, and he is coming off a 2021 campaign in which he produced more than 1,300 receiving yards. Memphis has allowed more passing yards (288.0 per game) than any team in the AAC this season, and the Tigers have the third-worst mark in the conference in total defense (400.2 yards allowed per game). Memphis has only seven sacks in five games, with opposing quarterbacks producing 8.0 yards per pass attempt in 2022.

Why Memphis can cover

Memphis is performing quite well on both sides and it features a havoc-creating defense. The Tigers have eight interceptions in five games, most of any AAC program, and opponents are connecting on only 61.3% of pass attempts. Memphis is also stuffing the run effectively, giving up 112.2 rushing yards per game and 3.2 yards per carry this season. Houston's offensive line has allowed the third-most sacks (13) of any AAC program, and the Cougars are generating only 3.9 yards per rush attempt. 

On the opposite side, Memphis is putting up more than 34 points and 400 total yards per game, and the Tigers have only one interception in five contests. Sophomore quarterback Seth Henigan is playing well with 1,276 passing yards and 149 rushing yards this season, and no team has allowed more passing touchdowns (12) in the AAC than Houston. The Rockets are in the bottom tier of the conference in points allowed (34.0 per game), total defense (408.4 yards allowed per game) and passing yards allowed (273.6 per game), and Memphis should have avenues to find success.

How to make Houston vs. Memphis picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 67 points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's CFB picks here.

So who wins Houston vs. Memphis? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Houston vs. Memphis spread you need to jump on Friday, all from the model that has crushed its college football picks, and find out.