The Washington Huskies will look to continue their recent domination over the Arizona Wildcats when they meet in a Pac-12 Conference crossover matchup on Friday night. The Huskies (2-4, 1-2), who have lost two in a row, have won four consecutive in the series, including a 44-27 win last year in Seattle. The Wildcats (0-6, 0-3), who have lost 18 in a row, last defeated Washington at home in 2014. Washington holds a 23-11-1 edge in the all-time series.

Kickoff from Arizona Stadium in Tucson, Ariz., will be at 10:30 p.m. ET. Both teams have had a hard time taking care of the football. Washington has a minus-3 turnover differential, tied for 108th in the country, while Arizona is 129th at minus-8. The Huskies are favored by 17.5 points in the latest Washington vs. Arizona odds from Caesars Sportsbook, while the over-under for total points scored is 45.5. Before making any Arizona vs. Washington picks, you need to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has locked in on Washington vs. Arizona and revealed its picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds and trends for Arizona vs. Washington:  

  • Washington vs. Arizona spread: Washington -17.5
  • Washington vs. Arizona over-under: 45.5 points
  • Washington vs. Arizona money line: Washington -900, Arizona +600
  • WAS: The Huskies are 4-0 against the spread in their last four Friday games
  • ARIZ: The under is 5-1 in the Wildcats' last six games as a home underdog

Why Washington can cover

The Huskies have done a good job limiting opposing offenses and boast a solid linebacking corps. Sophomores Edefuan Ulofoshio and Jackson Sirmon are at the heart of that unit. Ulofoshio leads the team in tackles with 51, including 25 solo, and has one pass breakup. He was a Pro Football Focus preseason first-team All-American in 2021 and was second-team All-Pac-12 in 2020, starting all four games. He made a team-high 47 tackles.

Sirmon is second on the team with 43 tackles, including 26 solo, and one forced fumble. He has played in all six games this season and made a career-high 12 tackles, including seven solo, at Michigan on Sept. 11. He started all four games in 2020, and made three tackles and 1 ½ tackles for loss against Arizona. Simon was named to the 2019 and 2020 Pac-12 Academic Honor Roll.

Why Arizona can cover

Although the Wildcats have yet to crack the win column, they're showing some signs of improvement. Defensively, they have held their opponents to under 400 yards of total offense four times this season after having done that once through the 2019 and 2020 seasons. Arizona is also fifth in the Pac-12 in total defense, allowing 372 yards per game. The Wildcats haven't finished higher than eighth in the conference since 2010, which is also the last time they allowed fewer than 400 yards per game for the year.

With sophomore running back Drake Anderson questionable for the game due to injury, sophomore Michael Wiley and freshman Jalen John may get a bigger workload. Wiley is second on the team in rushing, carrying 58 times for 185 yards (3.2 average). In three games, John has carried 18 times for 111 yards (6.2 average). John carried 11 times for 71 yards (6.5 average) in the 34-0 loss at Colorado last week.

How to make Arizona vs. Washington picks

The model says to go under the total as the teams combine for 45 points in the simulations. It also says one side of the spread has all the value. You can see which side to back at SportsLine.

So who wins Washington vs. Arizona? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread to back, all from the advanced model on a 22-9 run on its top-rated college football side picks, and find out.