The Week 2 NFL schedule will conclude with a Monday Night Football doubleheader as the Bills host the Titans and the Vikings visit the Eagles. Titans vs. Bills will kick off at 7:15 p.m. ET, while Vikings vs. Eagles starts at 8:30 p.m. ET. The two-game slate means you'll need to alter your NFL DFS strategy. It's a loaded NFL DFS player pool with superstars like Josh Allen, Derrick Henry, A.J. Brown and Justin Jefferson available, but affording those upper-echelon talents will require you to make sacrifices elsewhere in your NFL DFS lineups.

Which affordable role players should you plug into your Monday Night Football DFS lineups? Which quarterback-wide receiver tandems should you be including in your NFL DFS stacks for a rare Week 2 Monday Night Football doubleheader? Before you make your NFL DFS picks for Monday Night Football, be sure to check out the NFL DFS advice and strategy from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to Titans vs. Bills and Vikings vs. Eagles and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Monday Night Football

One of McClure's top NFL DFS picks for Monday Night Football is Eagles wide receiver A.J. Brown ($7,200 on DraftKings and $8,000 on FanDuel). After establishing himself as one of the premier big-play receivers in the NFL during three seasons with the Titans, Brown was traded to the Eagles during the 2022 NFL Draft and already established himself as the alpha male in the Philadelphia wide receivers' room.

Brown's debut with the Eagles ended with 10 catches for 155 yards in a win over the Lions. Brown was responsible for 63.8 percent of Jalen Hurts' passing yardage and no other player on the team was targeted more than four times. Now, he'll take on a Vikings pass defense that ranked 28th in the NFL last season.

McClure's optimal NFL DFS strategy also includes rostering Vikings running back Dalvin Cook ($8,200 on DraftKings and $7,900 on FanDuel). Cook is a home-run hitter with game-breaking burst out of the backfield and he's piled up stellar numbers over the last three seasons despite missing eight games due to various injuries.

Cook has rushed for 3,851 yards and 35 touchdowns during that span and also caught 131 passes for 1,104 yards and a score. In a Week 1 win over the Packers, he carried the ball 20 times for 90 yards and was also targeted five times in the passing game, catching three balls for 18 yards. Now, he gets a juicy matchup against an Eagles run defense that allowed D'Andre Swift to pile up 175 scrimmage yards and a touchdown last week. See the rest of McClure's NFL DFS picks here.

How to set NFL DFS lineups for Monday Night Football

McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here

So who is Mike McClure putting in his optimal NFL DFS lineups for Bills vs. Titans and Eagles vs. Vikings? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with over $2 million in winnings, and find out.